ASB3

Protein-coding gene in the species Homo sapiens
ASB3
Identifiers
AliasesASB3, ASB-3, ankyrin repeat and SOCS box containing 3
External IDsOMIM: 605760; MGI: 1929749; HomoloGene: 9391; GeneCards: ASB3; OMA:ASB3 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ASB3
Genomic location for ASB3
Band2p16.2Start53,532,672 bp[1]
End53,860,160 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for ASB3
Genomic location for ASB3
Band11 A4|11 18.19 cMStart30,835,416 bp[2]
End31,052,704 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • ventricular zone

  • ganglionic eminence

  • middle temporal gyrus

  • endothelial cell

  • tibia

  • corpus callosum

  • entorhinal cortex

  • testicle

  • postcentral gyrus
Top expressed in
  • spermatocyte

  • endocardial cushion

  • medial ganglionic eminence

  • granulocyte

  • spermatid

  • ventricular zone

  • cumulus cell

  • otic placode

  • lumbar spinal ganglion

  • genital tubercle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • ubiquitin protein ligase binding
  • ubiquitin-protein transferase activity
Cellular component
  • cytoplasm
  • nucleus
  • ubiquitin ligase complex
  • cytosol
Biological process
  • protein ubiquitination
  • intracellular signal transduction
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51130

65257

Ensembl

ENSG00000115239

ENSMUSG00000020305

UniProt

Q9Y575

Q9WV72

RefSeq (mRNA)

NM_145863
NM_001201965
NM_016115

NM_023906

RefSeq (protein)

NP_001157637

NP_076395

Location (UCSC)Chr 2: 53.53 – 53.86 MbChr 11: 30.84 – 31.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.[5][6]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115239 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020305 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE (May 2005). "Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II". Mol Cell Biol. 25 (11): 4716–26. doi:10.1128/MCB.25.11.4716-4726.2005. PMC 1140645. PMID 15899873.
  6. ^ a b "Entrez Gene: ASB3 ankyrin repeat and SOCS box-containing 3".

Further reading

  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene. 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
  • Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336. PMID 11509662.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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