Arecaidine
Chemical compound
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Other names | Methylguvacine; Arecaine; N-Methylguvacine |
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Formula | C7H11NO2 |
Molar mass | 141.170 g·mol−1 |
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Arecaidine is a bio-active alkaloid in areca nuts.[1] It is a competitive GABA reuptake inhibitor.[2] Lime is said to hydrolyse arecoline to arecaidine[2]
References
- ^ Voigt V, Laug L, Zebisch K, Thondorf I, Markwardt F, Brandsch M (April 2013). "Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1)". The Journal of Pharmacy and Pharmacology. 65 (4): 582–590. doi:10.1111/jphp.12006. PMID 23488788. S2CID 27577546.
- ^ a b Johnston GA, Krogsgaard-Larsen P, Stephanson A (December 1975). "Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake". Nature. 258 (5536): 627–628. Bibcode:1975Natur.258..627J. doi:10.1038/258627a0. PMID 1207742. S2CID 4147760.
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GABATooltip γ-Aminobutyric acid metabolism and transport modulators
GATTooltip GABA transporter |
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VIAATTooltip Vesicular inhibitory amino acid transporter |
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GADTooltip Glutamate decarboxylase |
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GABA-TTooltip γ-Aminobutyrate aminotransferase |
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Antivitamin B6 |
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- See also
- Receptor/signaling modulators
- GABA receptor modulators
- GABAA receptor positive modulators
- Glutamate metabolism/transport modulators