CNOT2 |
---|
|
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
List of PDB id codes |
---|
4C0D, 4C0F, 5FU6, 5FU7 |
|
|
Identifiers |
---|
Aliases | CNOT2, CDC36, NOT2, NOT2H, HSPC131, CCR4-NOT transcription complex subunit 2, IDNADFS |
---|
External IDs | OMIM: 604909; MGI: 1919318; HomoloGene: 40953; GeneCards: CNOT2; OMA:CNOT2 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 12 (human)[1] |
---|
| Band | 12q15 | Start | 70,243,002 bp[1] |
---|
End | 70,354,993 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 10 (mouse)[2] |
---|
| Band | 10|10 D2 | Start | 116,321,066 bp[2] |
---|
End | 116,417,416 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - oocyte
- secondary oocyte
- Achilles tendon
- nipple
- epithelium of nasopharynx
- human penis
- epithelium of colon
- ganglionic eminence
- skin of abdomen
- cerebellar cortex
|
| Top expressed in | - genital tubercle
- ciliary body
- internal carotid artery
- external carotid artery
- medullary collecting duct
- iris
- tail of embryo
- primitive streak
- retinal pigment epithelium
- cumulus cell
|
| More reference expression data |
|
---|
BioGPS | | More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - poly(A)-specific ribonuclease activity
- transcription coregulator activity
- protein binding
| Cellular component | - cytoplasm
- membrane
- CCR4-NOT complex
- P-body
- CCR4-NOT core complex
- nucleus
- cytosol
- plasma membrane
| Biological process | - nuclear-transcribed mRNA poly(A) tail shortening
- negative regulation of translation
- regulation of transcription, DNA-templated
- regulation of transcription by RNA polymerase II
- regulation of stem cell population maintenance
- negative regulation of transcription by RNA polymerase II
- transcription, DNA-templated
- multicellular organism development
- positive regulation of cytoplasmic mRNA processing body assembly
- trophectodermal cell differentiation
- gene silencing
- negative regulation of intracellular estrogen receptor signaling pathway
- regulation of translation
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- RNA phosphodiester bond hydrolysis, exonucleolytic
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | |
---|
NM_001199302 NM_001199303 NM_014515 |
| NM_001037846 NM_001037847 NM_001037848 NM_028082 NM_001359247
|
---|
NM_001359248 NM_001359249 NM_001359250 NM_001359251 NM_001359252 NM_001359253 NM_001359563 |
|
---|
RefSeq (protein) | |
---|
NP_001186231 NP_001186232 NP_055330 |
| NP_001032935 NP_001032936 NP_001032937 NP_082358 NP_001346176
|
---|
NP_001346177 NP_001346178 NP_001346179 NP_001346180 NP_001346181 NP_001346182 NP_001346492 |
|
---|
Location (UCSC) | Chr 12: 70.24 – 70.35 Mb | Chr 10: 116.32 – 116.42 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|