CRISP3

Protein-coding gene in the species Homo sapiens

CRISP3

Identifiers

Aliases

CRISP3, Aeg2, CRISP-3, CRS3, SGP28, dJ442L6.3, cysteine rich secretory protein 3

External IDs

OMIM: 618062; HomoloGene: 136801; GeneCards: CRISP3; OMA:CRISP3 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p12.3	Start	49,727,376 bp^[1]
Band	6p12.3	End	49,744,437 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

right uterine tube

olfactory zone of nasal mucosa

trabecular bone

mucosa of pharynx

bone marrow

minor salivary glands

seminal vesicula

oral cavity

bone marrow cells

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	molecular function
Cellular component	specific granule extracellular exosome extracellular region extracellular space specific granule lumen tertiary granule lumen extracellular matrix membrane integral component of membrane
Biological process	defense response innate immune response neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10321


n/a

Ensembl


ENSG00000096006


n/a

UniProt


P54108


n/a

RefSeq (mRNA)


NM_006061 NM_001190986 NM_001368123


n/a

RefSeq (protein)


NP_001177915 NP_006052 NP_001355052


n/a

Location (UCSC)

Chr 6: 49.73 – 49.74 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Cysteine-rich secretory protein 3 is a cysteine-rich secretory protein that in humans is encoded by the CRISP3 gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000096006 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kratzschmar J, Haendler B, Eberspaecher U, Roosterman D, Donner P, Schleuning WD (Aug 1996). "The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3". Eur J Biochem. 236 (3): 827–36. doi:10.1111/j.1432-1033.1996.t01-1-00827.x. PMID 8665901.
^ Udby L, Calafat J, Sorensen OE, Borregaard N, Kjeldsen L (Sep 2002). "Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils". J Leukoc Biol. 72 (3): 462–9. doi:10.1189/jlb.72.3.462. PMID 12223513. S2CID 16537644.
^ "Entrez Gene: CRISP3 cysteine-rich secretory protein 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kjeldsen L, Cowland JB, Johnsen AH, Borregaard N (1996). "SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein". FEBS Lett. 380 (3): 246–50. doi:10.1016/0014-5793(96)00030-0. PMID 8601434. S2CID 12264254.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Cowland JB, Borregaard N (2000). "The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules". J. Leukoc. Biol. 66 (6): 989–95. doi:10.1002/jlb.66.6.989. PMID 10614782. S2CID 14944558.
Friess H, Ding J, Kleeff J, et al. (2002). "Identification of disease-specific genes in chronic pancreatitis using DNA array technology". Ann. Surg. 234 (6): 769–78, discussion 778–9. doi:10.1097/00000658-200112000-00008. PMC 1422136. PMID 11729383.
Udby L, Cowland JB, Johnsen AH, et al. (2002). "An ELISA for SGP28/CRISP-3, a cysteine-rich secretory protein in human neutrophils, plasma, and exocrine secretions". J. Immunol. Methods. 263 (1–2): 43–55. doi:10.1016/S0022-1759(02)00033-9. PMID 12009203.
Kosari F, Asmann YW, Cheville JC, Vasmatzis G (2003). "Cysteine-rich secretory protein-3: a potential biomarker for prostate cancer". Cancer Epidemiol. Biomarkers Prev. 11 (11): 1419–26. PMID 12433721.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liao Q, Kleeff J, Xiao Y, et al. (2003). "Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis". Histol. Histopathol. 18 (2): 425–33. PMID 12647793.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Udby L, Sørensen OE, Pass J, et al. (2004). "Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma". Biochemistry. 43 (40): 12877–86. doi:10.1021/bi048823e. PMID 15461460.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Udby L, Bjartell A, Malm J, et al. (2005). "Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tract". J. Androl. 26 (3): 333–42. doi:10.2164/jandrol.04132. PMID 15867000.
Udby L, Lundwall A, Johnsen AH, et al. (2005). "beta-Microseminoprotein binds CRISP-3 in human seminal plasma". Biochem. Biophys. Res. Commun. 333 (2): 555–61. doi:10.1016/j.bbrc.2005.05.139. PMC 1939934. PMID 15950934.
Bjartell A, Johansson R, Björk T, et al. (2006). "Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland". Prostate. 66 (6): 591–603. doi:10.1002/pros.20342. PMID 16388501. S2CID 20810349.
Bjartell AS, Al-Ahmadie H, Serio AM, et al. (2007). "Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy". Clin. Cancer Res. 13 (14): 4130–8. doi:10.1158/1078-0432.CCR-06-3031. PMC 2660867. PMID 17634540.
Laine M, Porola P, Udby L, et al. (2007). "Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sjögren's syndrome". Arthritis Rheum. 56 (8): 2575–84. doi:10.1002/art.22828. PMID 17665393.