Protein-coding gene in the species Homo sapiens
CYP2W1 |
---|
|
Identifiers |
---|
Aliases | CYP2W1, cytochrome P450 family 2 subfamily W member 1 |
---|
External IDs | OMIM: 615967; MGI: 3616076; HomoloGene: 69239; GeneCards: CYP2W1; OMA:CYP2W1 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 7 (human)[1] |
---|
| Band | 7p22.3 | Start | 983,181 bp[1] |
---|
End | 989,640 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 5 (mouse)[2] |
---|
| Band | 5|5 G2 | Start | 139,338,372 bp[2] |
---|
End | 139,342,788 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - buccal mucosa cell
- right adrenal cortex
- left adrenal cortex
- vena cava
- skin of abdomen
- skin of leg
- dorsal motor nucleus of vagus nerve
- internal globus pallidus
- sural nerve
- trabecular bone
|
| Top expressed in | - lip
- embryo
- zone of skin
- esophagus
- genital tubercle
- ileum
- colon
- stomach
- jejunum
- limb
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - iron ion binding
- oxidoreductase activity
- heme binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- metal ion binding
- monooxygenase activity
- arachidonic acid epoxygenase activity
- steroid hydroxylase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
| Cellular component | - cell surface
- plasma membrane
- endoplasmic reticulum lumen
- endoplasmic reticulum membrane
- endoplasmic reticulum
- membrane
- cytoplasm
- intracellular membrane-bounded organelle
| Biological process | - xenobiotic metabolic process
- epoxygenase P450 pathway
- organic acid metabolic process
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 7: 0.98 – 0.99 Mb | Chr 5: 139.34 – 139.34 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.[5]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[6] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000073067 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029541 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- ^ This article incorporates public domain material from "Entrez Gene: CYP2W1". Reference Sequence collection. National Center for Biotechnology Information.
External links
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hanzawa Y, Sasaki T, Mizugaki M, et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294. S2CID 5123383.
- Yoshioka H, Kasai N, Ikushiro S, et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
- Karlgren M, Gomez A, Stark K, et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
- Gomez A, Karlgren M, Edler D, et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics. 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
- Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
CYP1 | |
---|
CYP2 | |
---|
CYP3 (CYP3A) | |
---|
CYP4 | |
---|
CYP5-20 | |
---|
CYP21-49 | |
---|
CYP51-69 | |
---|
CYP71-99 | - CYP71 (C1, C2, C3, C4, Z6, AJ4, AV1, BA1)
- CYP72A1
- CYP73A1
- CYP74 (D1)
- CYP75 (A1, B1)
- CYP76 (B6, M7)
- CYP79 (A1, A2, B1, B2, B3, D1, D2, D3, D4)
- CYP80 (A1, B1, G2)
- CYP81 (E1, E3, E7, E9)
- CYP88D6
- CYP90C1
- CYP93E1
- CYP97C1
- CYP99A3
|
---|
CYP101-281 | |
---|
CYP301-499 | |
---|
CYP501-699 | |
---|
CYP701-999 | |
---|
| This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it. |