Cofilin-2

Protein found in humans
CFL2
Identifiers
AliasesCFL2, NEM7, cofilin 2
External IDsOMIM: 601443; MGI: 101763; HomoloGene: 129115; GeneCards: CFL2; OMA:CFL2 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for CFL2
Genomic location for CFL2
Band14q13.1Start34,709,113 bp[1]
End34,714,823 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for CFL2
Genomic location for CFL2
Band12|12 C1Start54,905,594 bp[2]
End54,909,662 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cardiac muscle tissue of right atrium

  • myocardium of left ventricle

  • deltoid muscle

  • tibialis anterior muscle

  • Skeletal muscle tissue of rectus abdominis

  • quadriceps femoris muscle

  • vastus lateralis muscle

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • muscle of thigh
Top expressed in
  • intercostal muscle

  • atrioventricular valve

  • temporal muscle

  • sternocleidomastoid muscle

  • vastus lateralis muscle

  • triceps brachii muscle

  • ankle

  • atrium

  • digastric muscle

  • muscle of thigh
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • actin binding
  • protein binding
  • actin filament binding
Cellular component
  • nuclear matrix
  • cytoplasm
  • extracellular exosome
  • intracellular anatomical structure
  • cytoskeleton
  • I band
  • nucleus
  • actin cytoskeleton
  • Z discdkac
  • extracellular space
Biological process
  • sarcomere organization
  • muscle cell cellular homeostasis
  • positive regulation of actin filament depolymerization
  • actin filament organization
  • actin filament depolymerization
  • skeletal muscle tissue development
  • actin filament fragmentation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1073

12632

Ensembl

ENSG00000165410

ENSMUSG00000062929

UniProt

Q9Y281
Q549N0

P45591

RefSeq (mRNA)

NM_001243645
NM_021914
NM_138638

NM_007688

RefSeq (protein)

NP_001230574
NP_068733
NP_619579
NP_068733.1
NP_619579.1

NP_031714

Location (UCSC)Chr 14: 34.71 – 34.71 MbChr 12: 54.91 – 54.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.[5][6]

Function

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner.[6] Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN), all of which regulate actin-filament dynamics.[7][8] The CFL2 gene encodes a skeletal muscle-specific isoform[9] localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins.[10]

Clinical significance

Mutations in the CFL2 gene are associated with nemaline myopathy. Deficiency of cofilin-2 may result in reduced depolymerization of actin filaments, causing their accumulation in nemaline bodies, minicores, and, possibly concentric laminated bodies.[11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165410 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062929 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CFL2 cofilin 2 (muscle)".
  6. ^ a b Gillett GT, Fox MF, Rowe PS, Casimir CM, Povey S (May 1996). "Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14". Ann. Hum. Genet. 60 (Pt 3): 201–11. doi:10.1111/j.1469-1809.1996.tb00423.x. PMID 8800436. S2CID 19565638.
  7. ^ Bamburg JR, McGough A, Ono S (September 1999). "Putting a new twist on actin: ADF/cofilins modulate actin dynamics". Trends Cell Biol. 9 (9): 364–70. doi:10.1016/S0962-8924(99)01619-0. PMID 10461190.
  8. ^ Maciver SK, Hussey PJ (2002). "The ADF/cofilin family: actin-remodeling proteins". Genome Biol. 3 (5): reviews3007. doi:10.1186/gb-2002-3-5-reviews3007. PMC 139363. PMID 12049672.
  9. ^ Vartiainen MK, Mustonen T, Mattila PK, et al. (January 2002). "The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics". Mol. Biol. Cell. 13 (1): 183–94. doi:10.1091/mbc.01-07-0331. PMC 65081. PMID 11809832.
  10. ^ Ono S, Ono K (March 2002). "Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics". J. Cell Biol. 156 (6): 1065–76. doi:10.1083/jcb.200110013. PMC 2173459. PMID 11901171.
  11. ^ Agrawal PB, Greenleaf RS, Tomczak KK, Lehtokari VL, Wallgren-Pettersson C, Wallefeld W, Laing NG, Darras BT, Maciver SK, Dormitzer PR, Beggs AH (January 2007). "Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2". Am. J. Hum. Genet. 80 (1): 162–7. doi:10.1086/510402. PMC 1785312. PMID 17160903.
  • GeneReviews/NCBI/NIH/UW entry on Nemaline Myopathy
  • Human CFL2 genome location and CFL2 gene details page in the UCSC Genome Browser.

Further reading

  • Thirion C, Stucka R, Mendel B, et al. (2001). "Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle". Eur. J. Biochem. 268 (12): 3473–82. doi:10.1046/j.1432-1327.2001.02247.x. PMID 11422377.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
  • Kudryashov DS, Galkin VE, Orlova A, et al. (2006). "Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface". J. Mol. Biol. 358 (3): 785–97. doi:10.1016/j.jmb.2006.02.029. PMID 16530787.
  • Nebl G, Meuer SC, Samstag Y (1996). "Dephosphorylation of serine 3 regulates nuclear translocation of cofilin". J. Biol. Chem. 271 (42): 26276–80. doi:10.1074/jbc.271.42.26276. PMID 8824278.
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Hillier LD, Lennon G, Becker M, et al. (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Endo M, Ohashi K, Sasaki Y, et al. (2003). "Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin". J. Neurosci. 23 (7): 2527–37. doi:10.1523/JNEUROSCI.23-07-02527.2003. PMC 6742113. PMID 12684437.
  • Coiras M, Camafeita E, Ureña T, et al. (2006). "Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression". Proteomics. 6 (Suppl 1): S63–73. doi:10.1002/pmic.200500437. PMID 16526095. S2CID 42878271.
  • Yang N, Higuchi O, Ohashi K, et al. (1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization". Nature. 393 (6687): 809–12. Bibcode:1998Natur.393..809Y. doi:10.1038/31735. PMID 9655398. S2CID 4326365.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Wu Y, Yoder A, Yu D, et al. (2008). "Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study". Retrovirology. 5 (1): 95. doi:10.1186/1742-4690-5-95. PMC 2576353. PMID 18928553.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Papalouka V, Arvanitis DA, Vafiadaki E, et al. (2009). "Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle". Mol. Cell. Biol. 29 (22): 6046–58. doi:10.1128/MCB.00654-09. PMC 2772566. PMID 19752190.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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