DDX42

Protein-coding gene in the species Homo sapiens
DDX42
Identifiers
AliasesDDX42, DDX42P, RHELP, RNAHP, SF3B8, SF3b125, DEAD-box helicase 42
External IDsOMIM: 613369; MGI: 1919297; HomoloGene: 49137; GeneCards: DDX42; OMA:DDX42 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for DDX42
Genomic location for DDX42
Band17q23.3Start63,773,603 bp[1]
End63,819,317 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for DDX42
Genomic location for DDX42
Band11|11 E1Start106,216,926 bp[2]
End106,249,139 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • right uterine tube

  • gastric mucosa

  • left ovary

  • right ovary

  • epithelium of colon

  • Achilles tendon

  • canal of the cervix

  • sural nerve

  • minor salivary glands
Top expressed in
  • neural layer of retina

  • ventricular zone

  • tail of embryo

  • neural tube

  • epiblast

  • dentate gyrus of hippocampal formation granule cell

  • lens

  • superior frontal gyrus

  • yolk sac

  • thymus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • protein binding
  • hydrolase activity
  • ATP binding
  • helicase activity
  • nucleic acid binding
  • RNA binding
Cellular component
  • cytoplasm
  • Cajal body
  • membrane
  • nucleus
  • nucleoplasm
  • cytosol
  • nuclear speck
  • nucleolus
Biological process
  • protein localization
  • RNA secondary structure unwinding
  • mRNA splicing, via spliceosome
  • regulation of apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11325

72047

Ensembl

ENSG00000198231

ENSMUSG00000020705

UniProt

Q86XP3

Q810A7

RefSeq (mRNA)

NM_007372
NM_203499

NM_028074

RefSeq (protein)

NP_031398
NP_987095

NP_082350
NP_001348569
NP_001348571
NP_001348572
NP_001348573

Location (UCSC)Chr 17: 63.77 – 63.82 MbChr 11: 106.22 – 106.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene.[5][6]

Function

This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.[6]

Interactions

DDX42 has been shown to interact with SF3B1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198231 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020705 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW, Kim HD, Seo YS (Apr 2000). "Identification of a novel human member of the DEAD box protein family". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1501 (1): 63–9. doi:10.1016/S0925-4439(00)00010-7. PMID 10727850.
  6. ^ a b "Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42".
  7. ^ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Uhlmann-Schiffler H, Jalal C, Stahl H (2006). "Ddx42p--a human DEAD box protein with RNA chaperone activities". Nucleic Acids Research. 34 (1): 10–22. doi:10.1093/nar/gkj403. PMC 1325199. PMID 16397294.
  • Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.


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