DHRS9

Protein-coding gene in the species Homo sapiens

DHRS9
Identifiers
AliasesDHRS9, 3-alpha-HSD, 3ALPHA-HSD, RDH-E2, RDH-TBE, RDH15, RDHL, RDHTBE, RETSDR8, SDR9C4, dehydrogenase/reductase (SDR family) member 9, dehydrogenase/reductase 9
External IDsOMIM: 612131; MGI: 2442798; HomoloGene: 26079; GeneCards: DHRS9; OMA:DHRS9 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DHRS9
Genomic location for DHRS9
Band2q31.1Start169,064,789 bp[1]
End169,096,167 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for DHRS9
Genomic location for DHRS9
Band2|2 C2Start69,210,789 bp[2]
End69,234,877 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nasal epithelium

  • epithelium of nasopharynx

  • epithelium of bronchus

  • bronchial epithelial cell

  • mucosa of transverse colon

  • palpebral conjunctiva

  • mucosa of sigmoid colon

  • mucosa of ileum

  • olfactory zone of nasal mucosa

  • sperm
Top expressed in
  • granulocyte

  • esophagus

  • placenta

  • lip

  • yolk sac

  • ileum

  • jejunum

  • zone of skin

  • ovary

  • stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • oxidoreductase activity
  • testosterone dehydrogenase (NAD+) activity
  • alcohol dehydrogenase (NAD+) activity
  • racemase and epimerase activity
  • NAD-retinol dehydrogenase activity
  • androsterone dehydrogenase activity
  • androstan-3-alpha,17-beta-diol dehydrogenase activity
Cellular component
  • intracellular membrane-bounded organelle
  • organelle membrane
  • integral component of endoplasmic reticulum membrane
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
Biological process
  • retinoic acid biosynthetic process
  • retinol metabolic process
  • 9-cis-retinoic acid biosynthetic process
  • epithelial cell differentiation
  • androgen metabolic process
  • progesterone metabolic process
  • lipid metabolism
  • steroid metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10170

241452

Ensembl

ENSG00000073737

ENSMUSG00000027068

UniProt

Q9BPW9

Q58NB6

RefSeq (mRNA)
NM_001142270
NM_001142271
NM_001289763
NM_005771
NM_199204

NM_001376924

NM_175512

RefSeq (protein)

NP_001135742
NP_001135743
NP_001276692
NP_954674
NP_001363853

NP_780721

Location (UCSC)Chr 2: 169.06 – 169.1 MbChr 2: 69.21 – 69.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dehydrogenase/reductase SDR family member 9 is an enzyme that in humans is encoded by the DHRS9 gene.[5][6][7][8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073737 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027068 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Soref CM, Di YP, Hayden L, Zhao YH, Satre MA, Wu R (Jun 2001). "Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol". J Biol Chem. 276 (26): 24194–202. doi:10.1074/jbc.M100332200. PMID 11304534.
  6. ^ Chetyrkin SV, Belyaeva OV, Gough WH, Kedishvili NY (Jun 2001). "Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties". J Biol Chem. 276 (25): 22278–86. doi:10.1074/jbc.M102076200. PMID 11294878.
  7. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  8. ^ "Entrez Gene: DHRS9 dehydrogenase/reductase (SDR family) member 9".

Further reading

  • Haeseleer F, Palczewski K (2000). "Short-chain dehydrogenases/Reductases in retina". Vertebrate Phototransduction and the Visual Cycle, Part B. Methods in Enzymology. Vol. 316. pp. 372–83. doi:10.1016/S0076-6879(00)16736-9. ISBN 978-0-12-182217-0. PMID 10800688.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Markova NG, Pinkas-Sarafova A, Karaman-Jurukovska N, et al. (2003). "Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase". Mol. Genet. Metab. 78 (2): 119–35. doi:10.1016/S1096-7192(02)00226-3. PMID 12618084.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Jette C, Peterson PW, Sandoval IT, et al. (2004). "The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L." J. Biol. Chem. 279 (33): 34397–405. doi:10.1074/jbc.M314021200. PMID 15190067.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Jones RJ, Dickerson S, Bhende PM, et al. (2007). "Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9". J. Biol. Chem. 282 (11): 8317–24. doi:10.1074/jbc.M608667200. PMID 17244623.
  • Riquelme P, Amodio G, Macedo C, Moreau A, Obermajer N, Brochhausen C, Ahrens N, Kekarainen T, Faendrich F, Cuturi C, Gregori S, Metes D, Schlitt HJ, Thomson AW, Geissler EK, Hutchinson JA (2017). "DHRS9 Is a Stable Marker of Human Regulatory Macrophages". Transplantation. 101 (11): 2731–38. doi:10.1097/TP.0000000000001814. PMC 6319563. PMID 28594751.


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