Frizzled-8

Protein-coding gene in the species Homo sapiens
FZD8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1IJY, 4F0A

Identifiers
AliasesFZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDsOMIM: 606146; MGI: 108460; HomoloGene: 40606; GeneCards: FZD8; OMA:FZD8 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for FZD8
Genomic location for FZD8
Band10p11.21Start35,638,247 bp[1]
End35,642,296 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for FZD8
Genomic location for FZD8
Band18 A1|18 4.91 cMStart9,212,163 bp[2]
End9,218,136 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • cartilage tissue

  • ganglionic eminence

  • retinal pigment epithelium

  • tendon of biceps brachii

  • trabecular bone

  • lactiferous duct

  • pancreatic epithelial cell

  • pancreatic ductal cell

  • spinal ganglia
Top expressed in
  • ventricular zone

  • hypoblast

  • calvaria

  • retinal pigment epithelium

  • left lobe of liver

  • ankle

  • ciliary body

  • molar

  • primitive endoderm

  • trigeminal ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transmembrane signaling receptor activity
  • signaling receptor binding
  • ubiquitin protein ligase binding
  • protein binding
  • signal transducer activity
  • PDZ domain binding
  • G protein-coupled receptor activity
  • Wnt-protein binding
  • Wnt-activated receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • Golgi apparatus
  • Wnt-Frizzled-LRP5/6 complex
Biological process
  • positive regulation of protein phosphorylation
  • positive regulation of JUN kinase activity
  • cell surface receptor signaling pathway
  • G protein-coupled receptor signaling pathway
  • angiogenesis
  • positive regulation of transcription by RNA polymerase II
  • multicellular organism development
  • negative regulation of transcription by RNA polymerase II
  • neuron differentiation
  • signal transduction
  • Wnt signaling pathway
  • T cell differentiation in thymus
  • non-canonical Wnt signaling pathway
  • canonical Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8325

14370

Ensembl

ENSG00000177283

ENSMUSG00000036904

UniProt

Q9H461

Q61091

RefSeq (mRNA)

NM_031866

NM_008058

RefSeq (protein)

NP_114072

NP_032084

Location (UCSC)Chr 10: 35.64 – 35.64 MbChr 18: 9.21 – 9.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.[5][6]

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177283 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036904 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.
  6. ^ a b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

Further reading

  • Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–4476. doi:10.1074/jbc.271.8.4468. PMID 8626800.
  • Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
  • Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–535. Bibcode:2000Natur.407..530T. doi:10.1038/35035117. PMID 11029007. S2CID 4400159.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. Bibcode:2001CBio...11..951S. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771. S2CID 15702819.
  • Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ (2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature. 412 (6842): 86–90. Bibcode:2001Natur.412...86D. doi:10.1038/35083601. PMID 11452312. S2CID 4303237.
  • Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–778. doi:10.1006/bbrc.2001.5430. PMID 11520064.
  • Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
  • Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell. 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084. S2CID 18567677.

External links

  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.
  • Overview of all the structural information available in the PDB for UniProt: Q9H461 (Human Frizzled-8 (FZD8)) at the PDBe-KB.


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  • 1ijy: CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MOUSE FRIZZLED 8 (MFZ8)
    1ijy: CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MOUSE FRIZZLED 8 (MFZ8)
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Neurotransmitter
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Miscellaneous
Taste, bitter
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Taste, sweet
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Class F: Frizzled & Smoothened
Frizzled
Smoothened

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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