GADD45GIP1

Protein-coding gene in the species Homo sapiens
GADD45GIP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J7Y, 3J9M

Identifiers
AliasesGADD45GIP1, CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1, GADD45G interacting protein 1
External IDsOMIM: 605162; MGI: 1914947; HomoloGene: 33474; GeneCards: GADD45GIP1; OMA:GADD45GIP1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GADD45GIP1
Genomic location for GADD45GIP1
Band19p13.13Start12,953,119 bp[1]
End12,957,223 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for GADD45GIP1
Genomic location for GADD45GIP1
Band8|8 C3Start85,558,151 bp[2]
End85,562,111 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • muscle of thigh

  • mucosa of transverse colon

  • left ventricle

  • gastrocnemius muscle

  • right auricle

  • triceps brachii muscle

  • anterior cingulate cortex

  • olfactory zone of nasal mucosa

  • right adrenal gland
Top expressed in
  • left lobe of liver

  • primary oocyte

  • digastric muscle

  • extraocular muscle

  • interventricular septum

  • right ventricle

  • temporal muscle

  • myocardium of ventricle

  • sternocleidomastoid muscle

  • adrenal gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • mitochondrial matrix
  • mitochondrial ribosome
  • nucleus
  • mitochondrion
  • ribosome
Biological process
  • cell cycle
  • mitochondrial translational elongation
  • mitochondrial translational termination
  • viral process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

90480

102060

Ensembl

ENSG00000179271

ENSMUSG00000033751

UniProt

Q8TAE8

Q9CR59

RefSeq (mRNA)

NM_052850

NM_183358

RefSeq (protein)

NP_443082

NP_899202

Location (UCSC)Chr 19: 12.95 – 12.96 MbChr 8: 85.56 – 85.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.[5][6][7]

GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.[8]

Interactions

GADD45GIP1 has been shown to interact with GADD45G,[9] GADD45B[9] and GADD45A.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179271 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033751 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Horikoshi N, Cong J, Kley N, Shenk T (Aug 1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochemical and Biophysical Research Communications. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
  6. ^ Görnemann J, Hofmann TG, Will H, Müller M (Nov 2002). "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins". Virology. 303 (1): 69–78. doi:10.1006/viro.2002.1670. PMID 12482659.
  7. ^ "Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1".
  8. ^ Kim SJ, Kwon Mc, Ryu MJ, Chung HK, Tadi S, Kim YK, et al. (2012). "CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane". Cell Metabolism. 16 (2): 274–283. doi:10.1016/j.cmet.2012.06.012. ISSN 1550-4131. PMID 22819524.
  9. ^ a b c Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.

Further reading

  • Ahn BH, Kim TH, Bae YS (Oct 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Molecules and Cells. 12 (2): 158–63. doi:10.1016/S1016-8478(23)17077-4. PMID 11710515.
  • Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Park KC, Song KH, Chung HK, Kim H, Kim DW, Song JH, Hwang ES, Jung HS, Park SH, Bae I, Lee IK, Choi HS, Shong M (Jan 2005). "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation". Molecular Endocrinology. 19 (1): 12–24. doi:10.1210/me.2004-0107. PMID 15459248.
  • Oh NS, Yoon SH, Lee WK, Choi JY, Min do S, Bae YS (Jan 2007). "Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation". Gene. 386 (1–2): 147–53. doi:10.1016/j.gene.2006.08.023. PMID 17069992.
  • Nakayama K, Nakayama N, Wang TL, Shih Ie-M (Sep 2007). "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor". Cancer Research. 67 (17): 8058–64. doi:10.1158/0008-5472.CAN-07-1357. PMID 17804717.
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