IMP4

Protein-coding gene in the species Homo sapiens

IMP4
Identifiers
AliasesIMP4, BXDC4, IMP4 homolog, U3 small nucleolar ribonucleoprotein, U3 small nucleolar ribonucleoprotein, IMP U3 small nucleolar ribonucleoprotein 4
External IDsOMIM: 612981; MGI: 106572; HomoloGene: 68891; GeneCards: IMP4; OMA:IMP4 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IMP4
Genomic location for IMP4
Band2q21.1Start130,342,877 bp[1]
End130,347,967 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for IMP4
Genomic location for IMP4
Band1 B|1 13.22 cMStart34,478,932 bp[2]
End34,488,437 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • gastrocnemius muscle

  • body of stomach

  • right lobe of liver

  • muscle of thigh

  • mucosa of transverse colon

  • left coronary artery

  • prefrontal cortex

  • granulocyte

  • apex of heart
Top expressed in
  • zygote

  • yolk sac

  • primary oocyte

  • morula

  • morula

  • embryo

  • epiblast

  • embryo

  • right kidney

  • secondary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • rRNA primary transcript binding
  • snoRNA binding
Cellular component
  • small-subunit processome
  • nucleolus
  • nucleus
  • nucleoplasm
  • fibrillar center
  • preribosome
  • Mpp10 complex
Biological process
  • ribosome biogenesis
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

92856

27993

Ensembl

ENSG00000136718

ENSMUSG00000026127

UniProt

Q96G21

Q8VHZ7

RefSeq (mRNA)
NM_033416
NM_001320304
NM_001320305
NM_001320306
NM_001320307

NM_001320309
NM_001320310
NM_001320311
NM_001371725
NM_001371726
NM_001371728
NM_001371730
NM_001371731
NM_001371732
NM_001371733
NM_001371734

NM_178601

RefSeq (protein)
NP_001307233
NP_001307234
NP_001307235
NP_001307236
NP_001307238

NP_001307239
NP_001307240
NP_219484
NP_001358654
NP_001358655
NP_001358657
NP_001358659
NP_001358660
NP_001358661
NP_001358662
NP_001358663

NP_848716

Location (UCSC)Chr 2: 130.34 – 130.35 MbChr 1: 34.48 – 34.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U3 small nucleolar ribonucleoprotein protein IMP4 is a protein that in humans is encoded by the IMP4 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136718 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026127 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  7. ^ "Entrez Gene: IMP4 IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)".

Further reading

  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Granneman S, Gallagher JE, Vogelzangs J, et al. (2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes". Nucleic Acids Res. 31 (7): 1877–87. doi:10.1093/nar/gkg300. PMC 152815. PMID 12655004.
  • Leary DJ, Terns MP, Huang S (2004). "Components of U3 snoRNA-containing complexes shuttle between nuclei and the cytoplasm and differentially localize in nucleoli: implications for assembly and function". Mol. Biol. Cell. 15 (1): 281–93. doi:10.1091/mbc.E03-06-0363. PMC 307547. PMID 14565981.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.


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