IPO9

Protein-coding gene in the species Homo sapiens
IPO9
Identifiers
AliasesIPO9, Imp9, importin 9
External IDsMGI: 1918944; HomoloGene: 5874; GeneCards: IPO9; OMA:IPO9 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for IPO9
Genomic location for IPO9
Band1q32.1Start201,829,149 bp[1]
End201,884,291 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for IPO9
Genomic location for IPO9
Band1|1 E4Start135,310,050 bp[2]
End135,358,237 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nipple

  • ventricular zone

  • pylorus

  • parietal lobe

  • ganglionic eminence

  • ventral tegmental area

  • postcentral gyrus

  • entorhinal cortex

  • cardia

  • inferior ganglion of vagus nerve
Top expressed in
  • neural layer of retina

  • hand

  • abdominal wall

  • ventricular zone

  • genital tubercle

  • superior frontal gyrus

  • tail of embryo

  • maxillary prominence

  • mandibular prominence

  • internal carotid artery
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • histone binding
  • protein binding
  • nuclear import signal receptor activity
Cellular component
  • cytoplasm
  • membrane
  • nucleus
  • nuclear envelope
  • cytosol
Biological process
  • protein transport
  • intracellular protein transport
  • protein import into nucleus
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55705

226432

Ensembl

ENSG00000198700

ENSMUSG00000041879

UniProt

Q96P70

Q91YE6

RefSeq (mRNA)

NM_018085

NM_153774
NM_001357575
NM_001357576
NM_001357577
NM_001357578

RefSeq (protein)

NP_060555

n/a

Location (UCSC)Chr 1: 201.83 – 201.88 MbChr 1: 135.31 – 135.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Importin-9 is a protein that in humans is encoded by the IPO9 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198700 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041879 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jakel S, Mingot JM, Schwarzmaier P, Hartmann E, Gorlich D (Feb 2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
  6. ^ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  7. ^ "Entrez Gene: IPO9 importin 9".

Further reading

  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Mühlhäusser P, Müller EC, Otto A, Kutay U (2001). "Multiple pathways contribute to nuclear import of core histones". EMBO Rep. 2 (8): 690–6. doi:10.1093/embo-reports/kve168. PMC 1084005. PMID 11493596.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lubert EJ, Sarge KD (2003). "Interaction between protein phosphatase 2A and members of the importin beta superfamily". Biochem. Biophys. Res. Commun. 303 (3): 908–13. doi:10.1016/S0006-291X(03)00434-0. PMID 12670497.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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