Kayarat Saikrishnan
Kayarat Saikrishnan is an Indian structural biologist, a Professor in the Department of Biology and the dean of student and campus activities in Indian Institute of Science Education and Research, Pune (IISER, Pune). He was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology for the year 2019 in Biological Sciences "for his outstanding contributions in the area of structural biology by providing remarkable insights into the functioning of restriction-modification enzymes, which play a crucial role in bacterial defense".[1][2]
Kayarat Saikrishnan secured Ph D in Molecular Biophysics from Indian Institute of Science, Bangalore in 2005 under the supervision of M. Vijayan.[3] He then worked as a Post-doctoral fellow in cancer research in the Clare Hall Laboratories, South Mimms, UK until 2009 and then served as visiting scientist, MRC Laboratory of Molecular Biology, Cambridge, UK. He joined IISER, Pune as an assistant professor in 2010 and promoted as associate professor in 2016.[4]
Research
Biological processes involving nucleic acid employ enzymes driven by motors energized by the hydrolysis of nucleoside triphosphate (NTP). Many of these enzymes which are sometimes referred to as protein machines have modular functional domains that act in concert to carry out a specific task. Disturbances in the coordination of these machines can be disastrous to the cell. Saikrishnan's research is focused on understanding how the mechanism of these complex enzymes coordinate their action and function. The tools of structural biology, biochemistry and biophysics are used the research. One of the model systems that is being studied is the NTP-dependent restriction-modification (RM) enzyme, a bacterial defense system against invading foreign DNA, such as bacteriophage DNA. These enzymes coordinate the activities of four functional domains – nuclease, helicase-like NTPase motor, methyltransferase and target recognition domain (TRD). Saikrishnan's team recently determined the first crystal structure of such an enzyme, the Type ISP RM enzyme. Biochemical and single-molecule biophysical studies carried out based on the structure revealed a new mechanism of double-strand DNA-break formation resulting from multiple nicks of the DNA strands.[4]
References
- ^ "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize for Science and Technology. CSIR Human Resource Development Group, New Delhi. Retrieved 2 November 2020.
- ^ Himanshu Nitnaware. "Shanti Swarup Bhatnagar award for IISER scientist". Pune Mirror. Pune Mirror. Retrieved 2 November 2020.
- ^ "M Vijayan, Past Students". Molecular Biophysics Unit. Indian Institute of Science, Bangalore. Retrieved 2 November 2020.
- ^ a b "Mechanism of Macromolecular Machines". IISER Pune. IISER, Pune. Retrieved 2 November 2020.
External links
- Kayarat Saikrishnan in Google Scholar
- Kayarat Saikrishnan in PubMed
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- Toppur Seethapathy Sadasivan (1960)
- M. S. Swaminathan (1961)
- Bimal Kumar Bachhawat (1962)
- Jagannath Ganguly (1963}
- Dilbagh Singh Athwal (1964)
- Chirayathumadom Venkatachalier Subramanian (1965)
- Hari Krishan Jain (1966)
- Neelamraju Ganga Prasada Rao (1966)
- Arun Kumar Sharma (1967)
- Tathamangalam Ananthanarayanan Venkitasubramanian (1968)
- Madhu Sudan Kanungo (1971)
- Narayana Balakrishnan Nair (1971)
- Birendra Bijoy Biswas (1972)
- Satish Chandra Maheshwari (1972)
- Bhyravabhotla Radhakrishna Murty (1973)
- Sardul Singh Guraya (1973)
- John Barnabas (1974)
- Obaid Siddiqi (1975)
- Archana Sharma (1975)
- Guru Prakash Dutta (1976)
- Kishan Singh (1976)
- Trichnopoly Chelvaraj Anand Kumar (1977)
- V. Sasisekharan (1978)
- Amar Nath Bhaduri (1979)
- M. K. Chandrashekaran (1979)
- Asis Datta (1980)
- Jamuna Sharan Singh (1980)
- Prafullachandra Vishnu Sane (1981)
- Sushil Kumar (1981)
- Sunil Kumar Podder (1982)
- Ramamirtha Jayaraman (1982)
- Govindarajan Padmanabhan (1983)
- Thavamani Jegajothivel Pandian (1984)
- K. R. K. Easwaran (1984)
- Chhitar Mal Gupta (1985)
- M. Vijayan (1985)
- Madhav Gadgil (1986)
- Avadhesha Surolia
- Sudhir Kumar Sopory
- Bhabatarak Bhattacharyya (1988)
- M. R. S. Rao (1988)
- Subhash Chandra Lakhotia (1989)
- Manju Ray (1989)
- Samir K. Brahmachari (1990)
- Virendra Nath Pandey (1991)
- Srinivas Kishanrao (1991)
- Kuppamuthu Dharmalingam (1992)
- Dipankar Chatterji (1992)
- Raghavendra Gadagkar (1993)
- M. R. N. Murthy (1993)
- Ramakrishnan Nagaraj (1994)
- Alok Bhattacharya (1994)
- Seyed E. Hasnain (1995)
- Kalappa Muniyappa (1995)
- Ghanshyam Swarup (1996)
- Vishweshwaraiah Prakash (1996)
- Jayaraman Gowrishankar (1997)
- Kanury Venkata Subba Rao (1997)
- K. VijayRaghavan (1998)
- Debi Prasad Sarkar (1998)
- Siddhartha Roy (1999)
- Valakunja Nagaraja (1999)
- Dinakar Mashnu Salunke (2000)
- Jayant B. Udgaonkar (2000)
- Umesh Varshney (2001)
- Raghavan Varadarajan (2002)
- Amitabha Mukhopadhyay (2002)
- Satyajit Mayor (2003)
- Gopal Chandra Kundu (2004)
- Ramesh Venkata Sonti (2004)
- Tapas Kumar Kundu (2005)
- Shekhar C. Mande (2005)
- Vinod Bhakuni (2006)
- Rajesh Sudhir Gokhale (2006)
- Upinder Singh Bhalla (2007)
- Narayanaswamy Srinivasan (2007)
- Gajendra Pal Singh Raghava (2008)
- L. S. Shashidhara (2008)
- Amitabh Joshi (2009)
- Bhaskar Saha (2009)
- Sanjeev Galande (2010)
- Shubha Tole (2010)
- Amit Prakash Sharma (2011)
- Rajan Sankaranarayanan (2011)
- Shantanu Chowdhury (2012)
- Suman Kumar Dhar (2012)
- Sathees Chukkurumbal Raghavan (2013)
- Roop Mallik (2014)
- Balasubramanian Gopal (2015)
- Rajeev Kumar Varshney (2015)
- Suvendra Nath Bhattacharyya (2016)
- Rishikesh Narayanan (2016)
- Deepak T. Nair (2017)
- Sanjeev Das (2017)
- Ganesh Nagaraju (2018)
- Thomas J. Pucadyil (2018)
- Kayarat Saikrishnan (2019)
- Subhadeep Chatterjee (2020)
- Vatsala Thirumalai (2020)
- Amit Singh (2021)
- Arun Kumar Shukla (2021)
- Ashwani Kumar (2022)
- Maddika Subba Reddy (2022)