Protein-coding gene in the species Homo sapiens
LAIR1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3KGR, 3RP1 |
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Identifiers |
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Aliases | LAIR1, CD305, LAIR-1, leukocyte associated immunoglobulin like receptor 1 |
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External IDs | OMIM: 602992; MGI: 105492; HomoloGene: 48097; GeneCards: LAIR1; OMA:LAIR1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 19 (human)[1] |
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| Band | 19q13.42 | Start | 54,351,384 bp[1] |
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End | 54,370,558 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7 A1|7 2.31 cM | Start | 4,006,401 bp[2] |
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End | 4,066,203 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - granulocyte
- appendix
- monocyte
- spleen
- blood
- lymph node
- bone marrow
- right lung
- placenta
- upper lobe of left lung
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| Top expressed in | - granulocyte
- spleen
- stroma of bone marrow
- zygote
- mesenteric lymph nodes
- secondary oocyte
- lumbar subsegment of spinal cord
- blood
- supraoptic nucleus
- thymus
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | | Cellular component | - integral component of membrane
- plasma membrane
- membrane
- specific granule membrane
- tertiary granule membrane
| Biological process | - adaptive immune response
- regulation of immune response
- immune system process
- neutrophil degranulation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | ENSG00000276053 ENSG00000276163 ENSG00000278154 ENSG00000274110 ENSG00000167613
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n/a |
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UniProt | | |
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RefSeq (mRNA) | NM_001289023 NM_001289025 NM_001289026 NM_001289027 NM_002287
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NM_021706 NM_021708 |
| NM_001113474 NM_178611 NM_001302675 NM_001302676 NM_001302677
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NM_001302681 NM_001302682 NM_001302683 |
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RefSeq (protein) | NP_001275952 NP_001275954 NP_001275955 NP_001275956 NP_002278
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NP_068352 |
| NP_001106945 NP_001289604 NP_001289605 NP_001289606 NP_001289610
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NP_001289611 NP_001289612 NP_848726 |
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Location (UCSC) | Chr 19: 54.35 – 54.37 Mb | Chr 7: 4.01 – 4.07 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[5][6] LAIR1 has also been designated as CD305 (cluster of differentiation 305).
Function
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells.[7] Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[6]
Interactions
LAIR1 has been shown to interact with PTPN11[5][8] and PTPN6.[5][8][9][10][11]
References
- ^ a b c ENSG00000276163, ENSG00000278154, ENSG00000274110, ENSG00000167613 GRCh38: Ensembl release 89: ENSG00000276053, ENSG00000276163, ENSG00000278154, ENSG00000274110, ENSG00000167613 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055541 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (September 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. hdl:2066/26173. PMID 9285412.
- ^ a b "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1".
- ^ van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (October 1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". European Journal of Immunology. 29 (10): 3160–7. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327.
- ^ a b Fournier N, Chalus L, Durand I, Garcia E, Pin JJ, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates EE, Garrone P (August 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. 165 (3): 1197–209. doi:10.4049/jimmunol.165.3.1197. PMID 10903717.
- ^ Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ (February 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
- ^ Mousseau DD, Banville D, L'Abbé D, Bouchard P, Shen SH (February 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta" (PDF). J. Biol. Chem. 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. PMID 10660620.
- ^ Xu Mj, Zhao R, Zhao ZJ (June 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. doi:10.1074/jbc.M001313200. PMID 10764762.
Further reading
- Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. doi:10.1046/j.1365-3083.1999.00580.x. PMID 10404045. S2CID 10345478.
- Meyaard L (1999). "LAIR-1, a Widely Distributed Human ITIM-Bearing Receptor on Hematopoietic Cells". Immunoreceptor Tyrosine-based Inhibition Motifs. Current Topics in Microbiology 244 and Immunology. Vol. 244. pp. 151–7. doi:10.1007/978-3-642-58537-1_13. ISBN 978-3-540-65789-7. PMID 10453657.
{{cite book}}
: |journal=
ignored (help) - Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents. 17 (4): 330–3. PMID 15065762.
- Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. PMID 9692876. S2CID 21655416.
- Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. doi:10.4049/jimmunol.162.10.5800. PMID 10229813. S2CID 14882830.
- Poggi A, Pellegatta F, Leone BE, Moretta L, Zocchi MR (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. PMID 11069054.
- Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
- Saverino D, Fabbi M, Merlo A, Ravera G, Grossi CE, Ciccone E (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. doi:10.1016/S0198-8859(02)00409-3. PMID 12072189.
- Aoukaty A, Lee IF, Wu J, Tan R (2003). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. doi:10.1023/A:1022580929226. PMID 12757266. S2CID 31461585.
- Verbrugge A, de Ruiter T, Clevers H, Meyaard L (2003). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. doi:10.1093/intimm/dxg134. PMID 14565933.
- De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, Narita M, Grutzmeier S, Sönnerborg A, Chiodi F (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood. 103 (6): 2180–6. doi:10.1182/blood-2003-07-2375. PMID 14604962.
External links
- LAIR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q6GTX8 (Leukocyte-associated immunoglobulin-like receptor 1) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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