MARCH6

Protein-coding gene in the species Homo sapiens
MARCHF6
Identifiers
AliasesMARCHF6, DOA10, MARCH-VI, RNF176, TEB4, membrane associated ring-CH-type finger 6, MARCH6, FAME3
External IDsOMIM: 613297; MGI: 2442773; HomoloGene: 4301; GeneCards: MARCHF6; OMA:MARCHF6 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MARCHF6
Genomic location for MARCHF6
Band5p15.2Start10,353,695 bp[1]
End10,440,388 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for MARCHF6
Genomic location for MARCHF6
Band15|15 B2Start31,456,037 bp[2]
End31,531,199 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • endothelial cell

  • glutes

  • Region I of hippocampus proper

  • middle temporal gyrus

  • cerebellar vermis

  • dorsal motor nucleus of vagus nerve

  • corpus callosum

  • pons

  • postcentral gyrus
Top expressed in
  • extensor digitorum longus muscle

  • cingulate gyrus

  • plantaris muscle

  • lateral septal nucleus

  • median eminence

  • ventromedial nucleus

  • subiculum

  • arcuate nucleus

  • amygdala

  • anterior amygdaloid area
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • enzyme binding
  • ubiquitin-specific protease binding
  • zinc ion binding
  • ubiquitin conjugating enzyme binding
  • ubiquitin protein ligase activity
  • metal ion binding
  • ubiquitin-protein transferase activity
  • transferase activity
  • protein binding
Cellular component
  • integral component of membrane
  • integral component of endoplasmic reticulum membrane
  • ER ubiquitin ligase complex
  • membrane
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • endoplasmic reticulum quality control compartment
Biological process
  • protein K48-linked ubiquitination
  • proteasomal protein catabolic process
  • ERAD pathway
  • protein ubiquitination
  • endoplasmic reticulum mannose trimming
  • ubiquitin-dependent ERAD pathway
  • proteasome-mediated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10299

223455

Ensembl

ENSG00000145495

ENSMUSG00000039100

UniProt

O60337

Q6ZQ89

RefSeq (mRNA)

NM_001270660
NM_001270661
NM_005885

NM_172606

RefSeq (protein)

NP_001257589
NP_001257590
NP_005876

NP_766194
NP_001389808

Location (UCSC)Chr 5: 10.35 – 10.44 MbChr 15: 31.46 – 31.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase MARCH6 is an enzyme that in humans is encoded by the MARCH6 gene.[5][6]

Gene name error in Excel

Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH6 gene in Microsoft Excel.[7] This is due to Excel's autocorrect feature treating the text "MARCH6" as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.[8] The issue can be prevented by using an alias name (such as MARCHF6), prepending with an apostrophe ('), or preformatting the cell as text.

See also

  • iconBiology portal
  • List of EC numbers (EC 3)

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145495 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039100 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
  6. ^ "Entrez Gene: MARCH6 membrane-associated ring finger (C3HC4) 6".
  7. ^ Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, et al. (June 2004). "Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics". BMC Bioinformatics. 5 (1): 80. doi:10.1186/1471-2105-5-80. PMC 459209. PMID 15214961.
  8. ^ Ziemann M, Eren Y, El-Osta A (August 2016). "Gene name errors are widespread in the scientific literature". Genome Biology. 17 (1): 177. doi:10.1186/s13059-016-1044-7. PMC 4994289. PMID 27552985.

Further reading

  • Kreft SG, Wang L, Hochstrasser M (2006). "Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)". J. Biol. Chem. 281 (8): 4646–53. doi:10.1074/jbc.M512215200. PMID 16373356.
  • Hassink G, Kikkert M, van Voorden S, et al. (2005). "TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum". Biochem. J. 388 (Pt 2): 647–55. doi:10.1042/BJ20041241. PMC 1138973. PMID 15673284.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Swanson R, Locher M, Hochstrasser M (2001). "A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation". Genes Dev. 15 (20): 2660–74. doi:10.1101/gad.933301. PMC 312819. PMID 11641273.
  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.


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