MDN1

Protein-coding gene in the species Homo sapiens

MDN1

Identifiers

Aliases

MDN1, Rea1, midasin AAA ATPase 1

External IDs

OMIM: 618200; MGI: 1926159; HomoloGene: 39689; GeneCards: MDN1; OMA:MDN1 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q15	Start	89,642,498 bp^[1]
Band	6q15	End	89,819,794 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 A5\|4 14.3 cM	Start	32,657,119 bp^[2]
Band	4 A5\|4 14.3 cM	End	32,775,217 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

gonad

testicle

cerebellar hemisphere

right hemisphere of cerebellum

nucleus accumbens

putamen

primary visual cortex

caudate nucleus

substantia nigra

Top expressed in

tail of embryo

primitive streak

epiblast

genital tubercle

morula

spermatocyte

otic placode

embryo

paraventricular nucleus of hypothalamus

blastocyst

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding ATPase activity unfolded protein binding ATP binding nucleotide binding
Cellular component	nucleus intermediate filament cytoskeleton nucleolus membrane cytosol preribosome, large subunit precursor nucleoplasm cytoplasm
Biological process	rRNA processing ribosomal large subunit assembly protein-containing complex assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23195


100019

Ensembl


ENSG00000112159 ENSG00000288121


ENSMUSG00000058006

UniProt


Q9NU22


n/a

RefSeq (mRNA)


NM_014611


NM_001081392 NM_133874 NM_177666

RefSeq (protein)


NP_055426


n/a

Location (UCSC)

Chr 6: 89.64 – 89.82 Mb

Chr 4: 32.66 – 32.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

MDN1, midasin homolog (yeast) is a protein that in humans is encoded by the MDN1 gene.^[5] Midasin is a member AAA ATPase family.

References

^ ^a ^b ^c ENSG00000288121 GRCh38: Ensembl release 89: ENSG00000112159, ENSG00000288121 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058006 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MDN1, midasin homolog (yeast)". Retrieved 2011-09-20.

Garbarino JE, Gibbons IR (July 2002). "Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein". BMC Genomics. 3: 18. doi:10.1186/1471-2164-3-18. PMC 117441. PMID 12102729. van de Wijngaart DJ, Dubbink HJ, Molier M, de Vos C, Trapman J, Jenster G (November 2009). "Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression". Molecular Endocrinology. 23 (11): 1776–1786. doi:10.1210/me.2008-0280. PMC 5419170. PMID 19762545.