Monoamine-depleting agent
Drug class
Monoamine-depleting agents are a group of drugs which reversibly deplete one or more of the monoamine neurotransmitters, serotonin, dopamine, and norepinephrine.[1][2] One mechanism by which these agents act is by inhibiting reuptake by the vesicular monoamine transporters, VMAT1 and VMAT2.[2][3] Examples of monoamine-depleting agents include deutetrabenazine, oxypertine, reserpine, tetrabenazine, and valbenazine.[1][2][3] Tetrabenazine selectively depletes dopamine at low doses and is used as an animal model of amotivation.[4][5]
See also
- Monoamine neurotoxin
- Monoamine reuptake inhibitor
- Monoamine releasing agent
- Tetrabenazine § Animal model of motivational dysfunction
References
- ^ a b Carlsson A (1975). "Monoamine-depleting drugs". Pharmacol Ther B. 1 (3): 393–400. doi:10.1016/0306-039x(75)90045-8. PMID 772709.
- ^ a b c Vijayakumar D, Jankovic J (May 2016). "Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia". Drugs. 76 (7): 779–87. doi:10.1007/s40265-016-0568-1. PMID 27091214. S2CID 13570794.
- ^ a b Guay DR (August 2010). "Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders". Am J Geriatr Pharmacother. 8 (4): 331–73. doi:10.1016/j.amjopharm.2010.08.006. PMID 20869622.
- ^ Callaghan CK, Rouine J, O'Mara SM (2018). "Potential roles for opioid receptors in motivation and major depressive disorder". Prog Brain Res. 239: 89–119. doi:10.1016/bs.pbr.2018.07.009. PMID 30314570.
- ^ Salamone JD, Correa M, Ferrigno S, Yang JH, Rotolo RA, Presby RE (October 2018). "The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation". Pharmacol Rev. 70 (4): 747–762. doi:10.1124/pr.117.015107. PMC 6169368. PMID 30209181.
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(DRIsTooltip Dopamine reuptake inhibitors)
(NRIsTooltip Norepinephrine reuptake inhibitors)
(SRIsTooltip Serotonin reuptake inhibitors)
- Amiodarone
- Amphetamines (e.g., amphetamine, methamphetamine, MDMA)
- APP
- AZIK
- Bietaserpine
- Deserpidine
- Deutetrabenazine
- Dihydrotetrabenazine
- Efavirenz
- GBR-12935
- GZ-793A
- Ibogaine
- Ketanserin
- Lobeline
- Methoxytetrabenazine
- Reserpine
- Rose bengal
- Tetrabenazine
- Valbenazine
- Vanoxerine (GBR-12909)
- DAT enhancers: Luteolin
- DAT modulators: Agonist-like: SoRI-9804
- SoRI-20040; Antagonist-like: SoRI-20041
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins