NDUFC1

Protein-coding gene in the species Homo sapiens
NDUFC1
Identifiers
AliasesNDUFC1, KFYI, NADH:ubiquinone oxidoreductase subunit C1
External IDsOMIM: 603844; MGI: 1913627; HomoloGene: 1865; GeneCards: NDUFC1; OMA:NDUFC1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NDUFC1
Genomic location for NDUFC1
Band4q31.1Start139,266,880 bp[1]
End139,302,551 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for NDUFC1
Genomic location for NDUFC1
Band3|3 CStart51,312,098 bp[2]
End51,316,409 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • right ventricle

  • thoracic diaphragm

  • Skeletal muscle tissue of rectus abdominis

  • biceps brachii

  • beta cell

  • body of tongue

  • Skeletal muscle tissue of biceps brachii

  • kidney tubule

  • vastus lateralis muscle
Top expressed in
  • muscle of thigh

  • right kidney

  • digastric muscle

  • extraocular muscle

  • sternocleidomastoid muscle

  • myocardium of ventricle

  • temporal muscle

  • triceps brachii muscle

  • right ventricle

  • atrioventricular valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • NADH dehydrogenase (ubiquinone) activity
Cellular component
  • integral component of membrane
  • mitochondrial inner membrane
  • respirasome
  • membrane
  • mitochondrion
  • mitochondrial respiratory chain complex I
Biological process
  • mitochondrial electron transport, NADH to ubiquinone
  • mitochondrial respiratory chain complex I assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4717

66377

Ensembl

ENSG00000109390

ENSMUSG00000037152

UniProt

O43677

Q9CQY9

RefSeq (mRNA)
NM_002494
NM_001184986
NM_001184987
NM_001184988
NM_001184989

NM_001184990
NM_001184991

NM_025523

RefSeq (protein)
NP_001171915
NP_001171916
NP_001171917
NP_001171918
NP_001171919

NP_001171920
NP_002485

NP_079799

Location (UCSC)Chr 4: 139.27 – 139.3 MbChr 3: 51.31 – 51.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial is an enzyme that in humans is encoded by the NDUFC1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109390 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037152 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ton C, Hwang DM, Dempsey AA, Liew CC (Jan 1998). "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits". Biochem Biophys Res Commun. 241 (2): 589–94. doi:10.1006/bbrc.1997.7707. PMID 9425316.
  6. ^ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet. 82 (1–2): 115–9. doi:10.1159/000015082. PMID 9763677. S2CID 46818955.
  7. ^ "Entrez Gene: NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
  • Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.


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