Protein-coding gene in the species Homo sapiens
PCDHGC3 |
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Identifiers |
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Aliases | PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2, protocadherin gamma subfamily C, 3 |
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External IDs | OMIM: 603627; MGI: 1935201; HomoloGene: 31099; GeneCards: PCDHGC3; OMA:PCDHGC3 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 5 (human)[1] |
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| Band | 5q31.3 | Start | 141,475,947 bp[1] |
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End | 141,512,977 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 18 (mouse)[2] |
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| Band | 18 B3|18 19.67 cM | Start | 37,939,417 bp[2] |
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End | 37,974,926 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right frontal lobe
- right hemisphere of cerebellum
- anterior cingulate cortex
- C1 segment
- canal of the cervix
- right lung
- anterior pituitary
- right coronary artery
- upper lobe of left lung
- ascending aorta
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| Top expressed in | - ganglionic eminence
- cerebellum
- cerebellar cortex
- white adipose tissue
- olfactory bulb
- striatum of neuraxis
- lung
- hippocampus proper
- superior frontal gyrus
- lip
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - integral component of membrane
- plasma membrane
- membrane
- integral component of plasma membrane
| Biological process | - calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
- homophilic cell adhesion via plasma membrane adhesion molecules
- cell adhesion
- cell-cell signaling
- nervous system development
- synapse organization
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_032403 NM_002588 NM_032402 |
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RefSeq (protein) | |
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NP_002579 NP_115778 NP_115779 |
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Location (UCSC) | Chr 5: 141.48 – 141.51 Mb | Chr 18: 37.94 – 37.97 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene.[5][6][7]
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000240184 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000102918 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lynch ED, Lee MK, Morrow JE, Welcsh PL, Leon PE, King MC (Dec 1997). "Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous". Science. 278 (5341): 1315–8. Bibcode:1997Sci...278.1315L. doi:10.1126/science.278.5341.1315. PMID 9360932. S2CID 43492826.
- ^ Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993). "Protocadherins: a large family of cadherin-related molecules in central nervous system". EMBO J. 12 (6): 2249–56. doi:10.1002/j.1460-2075.1993.tb05878.x. PMC 413453. PMID 8508762.
- ^ a b "Entrez Gene: PCDHGC3 protocadherin gamma subfamily C, 3".
Further reading
- Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
- Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- Obata S, Sago H, Mori N, et al. (1997). "Protocadherin Pcdh2 shows properties similar to, but distinct from, those of classical cadherins". J. Cell Sci. 108 (12): 3765–73. doi:10.1242/jcs.108.12.3765. PMID 8719883.
- Obata S, Sago H, Mori N, et al. (1999). "A common protocadherin tail: multiple protocadherins share the same sequence in their cytoplasmic domains and are expressed in different regions of brain". Cell Adhes. Commun. 6 (4): 323–33. doi:10.3109/15419069809010791. PMID 9865466.
- Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
- Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. Bibcode:2000PNAS...97.3124W. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
- Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048. PMID 11230163.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Reiss K, Maretzky T, Haas IG, et al. (2006). "Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion". J. Biol. Chem. 281 (31): 21735–44. doi:10.1074/jbc.M602663200. PMID 16751190. S2CID 38025891.