PHACTR3

Protein-coding gene in the species Homo sapiens
PHACTR3
Identifiers
AliasesPHACTR3, C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
External IDsOMIM: 608725; MGI: 1921439; HomoloGene: 14482; GeneCards: PHACTR3; OMA:PHACTR3 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PHACTR3
Genomic location for PHACTR3
Band20q13.32-q13.33Start59,577,509 bp[1]
End59,847,711 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PHACTR3
Genomic location for PHACTR3
Band2|2 H4Start177,760,768 bp[2]
End177,980,285 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amygdala

  • internal globus pallidus

  • C1 segment

  • substantia nigra

  • corpus callosum

  • cingulate gyrus

  • anterior cingulate cortex

  • right frontal lobe

  • Brodmann area 9

  • hippocampus proper
Top expressed in
  • piriform cortex

  • olfactory tubercle

  • superior frontal gyrus

  • cingulate gyrus

  • globus pallidus

  • superior cervical ganglion

  • temporal lobe

  • visual cortex

  • primary motor cortex

  • hippocampus proper
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein phosphatase inhibitor activity
  • protein phosphatase 1 binding
  • actin binding
  • protein phosphatase regulator activity
Cellular component
  • nuclear matrix
  • nucleus
  • nucleoplasm
Biological process
  • negative regulation of phosphoprotein phosphatase activity
  • regulation of phosphoprotein phosphatase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116154

74189

Ensembl

ENSG00000087495

ENSMUSG00000027525

UniProt

Q96KR7

Q8BYK5

RefSeq (mRNA)
NM_001199505
NM_001199506
NM_001281507
NM_080672
NM_183244

NM_183246

NM_001007154
NM_001177789
NM_001177790
NM_001177791
NM_028806

RefSeq (protein)
NP_001186434
NP_001186435
NP_001268436
NP_542403
NP_899067

NP_899069

NP_001007155
NP_001171260
NP_001171261
NP_001171262
NP_083082

Location (UCSC)Chr 20: 59.58 – 59.85 MbChr 2: 177.76 – 177.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.[5][6]

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[6]

Interactions

PHACTR3 has been shown to interact with PPP1CA.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087495 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027525 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. Bibcode:2004PNAS..101.7187A. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502.
  6. ^ a b "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
  7. ^ Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

Further reading

  • Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human". Cytogenet. Genome Res. 115 (1): 23–9. doi:10.1159/000094797. PMID 16974080. S2CID 38349132.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.


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