PJA1

Protein-coding gene in the species Homo sapiens
PJA1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2L0B

Identifiers
AliasesPJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1
External IDsOMIM: 300420; MGI: 1101765; HomoloGene: 129620; GeneCards: PJA1; OMA:PJA1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for PJA1
Genomic location for PJA1
BandXq13.1Start69,160,851 bp[1]
End69,165,521 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for PJA1
Genomic location for PJA1
BandX C3|X 43.38 cMStart98,509,340 bp[2]
End98,514,879 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • corpus epididymis

  • ventricular zone

  • nucleus accumbens

  • middle temporal gyrus

  • anterior cingulate cortex

  • dorsolateral prefrontal cortex

  • prefrontal cortex

  • Brodmann area 9

  • caudate nucleus
Top expressed in
  • corneal stroma

  • CA3 field

  • perirhinal cortex

  • entorhinal cortex

  • Ileal epithelium

  • dorsomedial hypothalamic nucleus

  • ventromedial nucleus

  • paraventricular nucleus of hypothalamus

  • arcuate nucleus

  • central gray substance of midbrain
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • ubiquitin protein ligase activity
  • transferase activity
Cellular component
  • cytoplasm
Biological process
  • protein catabolic process
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64219

18744

Ensembl

ENSG00000181191

ENSMUSG00000034403

UniProt

Q8NG27

O55176

RefSeq (mRNA)

NM_001032396
NM_022368
NM_145119
NM_001382775
NM_001382776

NM_001083110
NM_001290555
NM_001290556
NM_008853

RefSeq (protein)

NP_001027568
NP_071763
NP_660095
NP_001369704
NP_001369705

NP_001076579
NP_001277484
NP_001277485
NP_032879

Location (UCSC)Chr X: 69.16 – 69.17 MbChr X: 98.51 – 98.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.[5][6]

Interactions

PJA1 has been shown to interact with UBE2D2[5] and MAGED1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181191 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034403 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
  6. ^ "Entrez Gene: PJA1 praja 1".
  7. ^ Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.

Further reading

  • Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, et al. (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
  • Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (March 2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". The Journal of Biological Chemistry. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
  • Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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