RBMS1

RBMS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X5O
Identifiers
Aliases	RBMS1, C2orf12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, SCR2, YC1, RNA binding motif single stranded interacting protein 1
External IDs	OMIM: 602310; MGI: 1861774; HomoloGene: 9640; GeneCards: RBMS1; OMA:RBMS1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.2 Start 160,272,151 bp[1] End 160,493,807 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.2 Start 60,580,537 bp[2] End 60,793,536 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis myocardium of left ventricle decidua cardiac muscle tissue of right atrium pericardium buccal mucosa cell tendon of biceps brachii skin of arm metanephric glomerulus skin of hip Top expressed in stroma of bone marrow gastrula ciliary body left lung lobe decidua iris skin of external ear conjunctival fornix endothelial cell of lymphatic vessel genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded DNA binding DNA binding double-stranded DNA binding protein binding nucleic acid binding RNA binding mRNA 3'-UTR binding poly(A) binding poly(U) RNA binding Cellular component nucleus cytoplasm cytosol ribonucleoprotein complex Biological process DNA replication RNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5937 56878 Ensembl ENSG00000153250 ENSMUSG00000026970 UniProt P29558 Q91W59 RefSeq (mRNA) NM_002897 NM_016836 NM_016839 NM_001141931 NM_001141932 NM_020296 RefSeq (protein) NP_002888 NP_058520 NP_001135403 NP_001135404 NP_064692 Location (UCSC) Chr 2: 160.27 – 160.49 Mb Chr 2: 60.58 – 60.79 Mb PubMed search [3] [4]
Wikidata
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RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene.^[5][6][7][8]

This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Multiple transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. Several of these were isolated by virtue of their binding to either strand of an upstream element of c-myc (MSSPs), or by phenotypic complementation of cdc2 and cdc13 mutants of yeast (scr2), or as a potential human repressor of HIV-1 and ILR-2 alpha promoter transcription (YC1). A pseudogene for this locus is found on chromosome 12.^[8]

RBMS1 has been shown to interact with Polymerase (DNA directed), alpha 1.^[9]

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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