RNF10

Protein-coding gene in the species Homo sapiens
RNF10
Identifiers
AliasesRNF10, RIE2, ring finger protein 10
External IDsOMIM: 615998; MGI: 1859162; HomoloGene: 40990; GeneCards: RNF10; OMA:RNF10 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for RNF10
Genomic location for RNF10
Band12q24.31Start120,533,480 bp[1]
End120,577,588 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for RNF10
Genomic location for RNF10
Band5 F|5 56.01 cMStart115,379,471 bp[2]
End115,410,957 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • muscle of thigh

  • gastrocnemius muscle

  • sural nerve

  • stromal cell of endometrium

  • anterior pituitary

  • ventricular zone

  • epithelium of colon

  • blood
Top expressed in
  • blood

  • neural layer of retina

  • entorhinal cortex

  • choroid plexus of fourth ventricle

  • lactiferous gland

  • perirhinal cortex

  • CA3 field

  • muscle of thigh

  • superior surface of tongue

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • metal ion binding
  • ubiquitin-protein transferase activity
Cellular component
  • cytoplasm
  • nucleus
Biological process
  • positive regulation of transcription, DNA-templated
  • positive regulation of myelination
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of Schwann cell proliferation
  • positive regulation of transcription by RNA polymerase II
  • protein autoubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9921

50849

Ensembl

ENSG00000022840

ENSMUSG00000041740

UniProt

Q8N5U6

Q3UIW5

RefSeq (mRNA)

NM_014868
NM_001330474

NM_016698
NM_001302448
NM_001302449

RefSeq (protein)

NP_001317403
NP_055683

NP_001289377
NP_001289378
NP_057907

Location (UCSC)Chr 12: 120.53 – 120.58 MbChr 5: 115.38 – 115.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.[5]

Function

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000022840 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041740 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RNF10 ring finger protein 10".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  • Seki N, Hattori A, Sugano S, Muramatsu M, Saito T (2000). "cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein". Journal of Human Genetics. 45 (1): 38–42. doi:10.1007/s100380050007. PMID 10697961.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (Jul 2005). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Molecular and Cellular Biochemistry. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786. S2CID 30515981.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.