RNF12

Protein-coding gene in the species Homo sapiens

RLIM
Identifiers
AliasesRLIM, NY-REN-43, RNF12, ring finger protein, LIM domain interacting, MRX61, TOKAS
External IDsOMIM: 300379; MGI: 1342291; HomoloGene: 7920; GeneCards: RLIM; OMA:RLIM - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for RLIM
Genomic location for RLIM
BandXq13.2Start74,582,976 bp[1]
End74,614,624 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for RLIM
Genomic location for RLIM
BandX 46.42 cM|X DStart103,000,769 bp[2]
End103,024,890 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • cartilage tissue

  • Achilles tendon

  • Brodmann area 46

  • postcentral gyrus

  • internal globus pallidus

  • entorhinal cortex

  • Brodmann area 23

  • tendon of biceps brachii

  • Pars compacta
Top expressed in
  • gastrula

  • cumulus cell

  • internal carotid artery

  • zygote

  • Gonadal ridge

  • external carotid artery

  • ectoderm

  • otic vesicle

  • Rostral migratory stream

  • otic placode
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transcription corepressor activity
  • metal ion binding
  • transferase activity
  • ubiquitin-protein transferase activity
  • ubiquitin protein ligase activity
  • protein binding
Cellular component
  • transcription repressor complex
  • nucleus
  • cytosol
  • nucleoplasm
Biological process
  • negative regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • protein ubiquitination
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • protein polyubiquitination
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • ubiquitin-dependent protein catabolic process
  • negative regulation of DNA-binding transcription factor activity
  • random inactivation of X chromosome
  • regulation of dosage compensation by inactivation of X chromosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51132

19820

Ensembl

ENSG00000131263

ENSMUSG00000056537

UniProt

Q9NVW2

Q9WTV7

RefSeq (mRNA)

NM_183353
NM_016120

NM_011276
NM_001358205

RefSeq (protein)

NP_057204
NP_899196

NP_035406
NP_001345134

Location (UCSC)Chr X: 74.58 – 74.61 MbChr X: 103 – 103.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[5][6]

Function

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[6] Functions in female mice as a regulator of X chromosome inactivation .

Interactions

RNF12 has been shown to interact with Estrogen receptor alpha.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131263 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056537 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
  6. ^ a b "Entrez Gene: RNF12 ring finger protein 12".
  7. ^ Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I (Jan 2009). "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. 69 (1): 128–36. doi:10.1158/0008-5472.CAN-08-1630. PMC 2713826. PMID 19117995.

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Hiratani I, Yamamoto N, Mochizuki T, Ohmori SY, Taira M (2003). "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions". Development. 130 (17): 4161–75. doi:10.1242/dev.00621. PMID 12874135. S2CID 18111062.
  • Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. Bibcode:2002Natur.416...99O. doi:10.1038/416099a. PMID 11882901. S2CID 4426785.
  • Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ, Jenkins NA, Lichter P, Bach I (2000). "Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors". Genomics. 69 (1): 120–30. doi:10.1006/geno.2000.6311. PMID 11013082.
  • Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
  • Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I (2010). "Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice". Nature. 467 (7318): 977–81. Bibcode:2010Natur.467..977S. doi:10.1038/nature09457. PMC 2967734. PMID 20962847.
  • Jiao B, Taniguchi-Ishigaki N, Güngör C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I (2013). "Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling". Mol Biol Cell. 24 (19): 3085–96. doi:10.1091/mbc.E13-05-0239. PMC 3784382. PMID 23904271.


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