RNF122

Protein-coding gene in the species Homo sapiens
RNF122
Identifiers
AliasesRNF122, ring finger protein 122
External IDsMGI: 1916117; HomoloGene: 11717; GeneCards: RNF122; OMA:RNF122 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for RNF122
Genomic location for RNF122
Band8p12Start33,547,754 bp[1]
End33,567,128 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for RNF122
Genomic location for RNF122
Band8|8 A3Start31,601,848 bp[2]
End31,621,510 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left uterine tube

  • right ovary

  • left ovary

  • muscle of thigh

  • ganglionic eminence

  • right auricle

  • gastrocnemius muscle

  • right uterine tube

  • granulocyte

  • upper lobe of left lung
Top expressed in
  • zygote

  • hand

  • Rostral migratory stream

  • maxillary prominence

  • mandibular prominence

  • primary oocyte

  • genital tubercle

  • superior cervical ganglion

  • secondary oocyte

  • ganglionic eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ubiquitin protein ligase activity
  • metal ion binding
  • protein binding
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • membrane
  • endoplasmic reticulum
  • endomembrane system
  • cytoplasm
Biological process
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • protein polyubiquitination
  • protein ubiquitination
  • negative regulation of mitochondrial membrane potential
  • positive regulation of apoptotic process
  • protein autoubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79845

68867

Ensembl

ENSG00000133874

ENSMUSG00000039328

UniProt

Q9H9V4

Q8BP31

RefSeq (mRNA)

NM_024787

NM_175136
NM_001368373
NM_001368374
NM_001368375

RefSeq (protein)

NP_079063

NP_780345
NP_001355302
NP_001355303
NP_001355304

Location (UCSC)Chr 8: 33.55 – 33.57 MbChr 8: 31.6 – 31.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 122 is a protein that in humans is encoded by the RNF122 gene.[5]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133874 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039328 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RNF122 ring finger protein 122".

Further reading

  • Koyama K, Sudo K, Nakamura Y (1995). "Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification". Genomics. 26 (2): 245–53. doi:10.1016/0888-7543(95)80207-3. PMID 7601449.
  • Saurin AJ, Borden KL, Boddy MN, Freemont PS (1996). "Does this have a familiar RING?". Trends Biochem. Sci. 21 (6): 208–14. doi:10.1016/s0968-0004(96)80017-x. PMID 8744354.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Wang L, Gao X, Gao P, et al. (2006). "Cell-based screening and validation of human novel genes associated with cell viability". Journal of Biomolecular Screening. 11 (4): 369–76. doi:10.1177/1087057106286654. PMID 16751333.
  • Wang L, Shi TP, Wang L, et al. (2006). "[Cloning, expression and subcellular localization of a novel human gene-RNF122]". Beijing da Xue Xue Bao. 38 (3): 239–43. PMID 16778963.


  • v
  • t
  • e