RNF39

Protein-coding gene in the species Homo sapiens
RNF39
Identifiers
AliasesRNF39, HZF, HZFW, LIRF, ring finger protein 39, FAP216
External IDsOMIM: 607524; MGI: 2156378; HomoloGene: 11891; GeneCards: RNF39; OMA:RNF39 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RNF39
Genomic location for RNF39
Band6p22.1Start30,070,266 bp[1]
End30,075,849 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for RNF39
Genomic location for RNF39
Band17|17 B1Start37,253,810 bp[2]
End37,258,878 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • skin of leg

  • minor salivary glands

  • vagina

  • olfactory zone of nasal mucosa

  • prostate

  • right uterine tube

  • testicle

  • body of stomach

  • ectocervix
Top expressed in
  • skin of abdomen

  • lip

  • esophagus

  • skin of external ear

  • skin of back

  • conjunctival fornix

  • hair follicle

  • decidua

  • gastrula

  • right lung lobe
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
Cellular component
  • cytoplasm
  • cellular component
Biological process
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80352

386454

Ensembl
ENSG00000230467
ENSG00000206500
ENSG00000204618
ENSG00000237733
ENSG00000227171

ENSG00000235022
ENSG00000236967
ENSG00000230332

ENSMUSG00000036492

UniProt

Q9H2S5

n/a

RefSeq (mRNA)

NM_170770
NM_025236
NM_170769

NM_001099632

RefSeq (protein)

NP_079512
NP_739575

n/a

Location (UCSC)Chr 6: 30.07 – 30.08 MbChr 17: 37.25 – 37.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 39 is a protein that in humans is encoded by the RNF39 gene.[5][6][7]

This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Alternative splicing results in three transcript variants encoding different isoforms.[7]

References

  1. ^ a b c ENSG00000206500, ENSG00000204618, ENSG00000237733, ENSG00000227171, ENSG00000235022, ENSG00000236967, ENSG00000230332 GRCh38: Ensembl release 89: ENSG00000230467, ENSG00000206500, ENSG00000204618, ENSG00000237733, ENSG00000227171, ENSG00000235022, ENSG00000236967, ENSG00000230332 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036492 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J (Dec 2000). "Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes". Mamm Genome. 11 (12): 1127–31. doi:10.1007/s003350010213. PMID 11130983. S2CID 22881226.
  6. ^ Matsuo R, Asada A, Fujitani K, Inokuchi K (Nov 2001). "LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein". Biochem Biophys Res Commun. 289 (2): 479–84. doi:10.1006/bbrc.2001.5975. PMID 11716498.
  7. ^ a b "Entrez Gene: RNF39 ring finger protein 39".

Further reading

  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Orimo A, Yamagishi T, Tominaga N, et al. (2000). "Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC". Biochem. Biophys. Res. Commun. 276 (1): 45–51. doi:10.1006/bbrc.2000.3380. PMID 11006080.
  • Hidaka M, Caruana G, Stanford WL, et al. (2000). "Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells". Mech. Dev. 90 (1): 3–15. doi:10.1016/S0925-4773(99)00234-8. PMID 10585558. S2CID 673064.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.