RUVBL2

Protein-coding gene in humans

RUVBL2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2CQA, 2XSZ, 3UK6

Identifiers

Aliases

RUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2

External IDs

OMIM: 604788; MGI: 1342299; HomoloGene: 4856; GeneCards: RUVBL2; OMA:RUVBL2 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	48,993,562 bp^[1]
Band	19q13.33	End	49,015,970 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B3	Start	45,071,184 bp^[2]
Band	7\|7 B3	End	45,087,520 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left testis

right testis

bronchial epithelial cell

right uterine tube

olfactory zone of nasal mucosa

mucosa of paranasal sinus

ventricular zone

parotid gland

tendon of biceps brachii

embryo

Top expressed in

epiblast

somite

tail of embryo

embryo

mandibular prominence

embryo

primitive streak

maxillary prominence

morula

ventricular zone

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleotide binding 5'-3' DNA helicase activity helicase activity unfolded protein binding DNA helicase activity ATPase activity protein binding identical protein binding chromatin DNA binding ATP binding hydrolase activity RNA polymerase II core promoter sequence-specific DNA binding TFIID-class transcription factor complex binding protein homodimerization activity ADP binding ATPase binding
Cellular component	membrane nuclear matrix NuA4 histone acetyltransferase complex intracellular anatomical structure nucleoplasm MLL1 complex extracellular exosome nucleus Swr1 complex R2TP complex cytoplasm centrosome cytosol Ino80 complex
Biological process	chromatin remodeling DNA recombination regulation of transcription, DNA-templated cellular response to UV histone H2A acetylation cellular response to estradiol stimulus transcription, DNA-templated positive regulation of histone acetylation cellular response to DNA damage stimulus establishment of protein localization to chromatin protein folding positive regulation of telomerase RNA localization to Cajal body histone H4 acetylation regulation of growth DNA repair positive regulation of transcription by RNA polymerase II DNA duplex unwinding box C/D snoRNP assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10856


20174

Ensembl


ENSG00000183207


ENSMUSG00000003868

UniProt


Q9Y230


Q9WTM5

RefSeq (mRNA)


NM_006666 NM_001321190 NM_001321191


NM_011304

RefSeq (protein)


NP_001308119 NP_001308120 NP_006657


NP_035434

Location (UCSC)

Chr 19: 48.99 – 49.02 Mb

Chr 7: 45.07 – 45.09 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

Function

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.^[5] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.^[6]

Interactions

RUVBL2 has been shown to interact with RuvB-like 1^[7] and Activating transcription factor 2.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183207 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003868 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (Feb 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". Journal of Molecular Biology. 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868.
^ "Entrez Gene: RUVBL2 RuvB-like 2 (E. coli)".
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z (Dec 2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology. 21 (24): 8398–413. doi:10.1128/MCB.21.24.8398-8413.2001. PMC 100004. PMID 11713276.

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