Protein-coding gene in the species Homo sapiens
SEPTIN14 |
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Identifiers |
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Aliases | SEPTIN14, septin 14, SEPT14 |
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External IDs | OMIM: 612140; MGI: 1921472; HomoloGene: 87501; GeneCards: SEPTIN14; OMA:SEPTIN14 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 7 (human)[1] |
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| Band | 7p11.2 | Start | 55,793,540 bp[1] |
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End | 55,862,755 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 G1.3 | Start | 129,760,455 bp[2] |
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End | 129,785,576 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right testis
- left testis
- gonad
- testicle
- blood
- monocyte
- endometrium
- anterior pituitary
- right lobe of liver
- spleen
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| Top expressed in | - zygote
- spermatocyte
- secondary oocyte
- spermatid
- primary oocyte
- testicle
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - nucleotide binding
- GTP binding
- protein binding
- GTPase activity
- molecular adaptor activity
| Cellular component | - cytoplasm
- cytoskeleton
- septin ring
- microtubule cytoskeleton
- septin complex
- septin filament array
| Biological process | - cell cycle
- cell division
- mitotic cytokinesis
- septin ring assembly
- cilium assembly
- cytoskeleton-dependent cytokinesis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 7: 55.79 – 55.86 Mb | Chr 5: 129.76 – 129.79 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Septin 14 is a protein that in humans is encoded by the SEPT14 gene.[5]
Function
SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000154997 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034219 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Septin 14".
Further reading
- Peterson EA, Kalikin LM, Steels JD, Estey MP, Trimble WS, Petty EM (November 2007). "Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin". Mammalian Genome. 18 (11): 796–807. doi:10.1007/s00335-007-9065-x. PMID 17922164. S2CID 9906543.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.