SPRED2

Protein-coding gene in the species Homo sapiens
SPRED2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2JP2

Identifiers
AliasesSPRED2, Spred-2, sprouty related EVH1 domain containing 2, NS14
External IDsOMIM: 609292; MGI: 2150019; HomoloGene: 24918; GeneCards: SPRED2; OMA:SPRED2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SPRED2
Genomic location for SPRED2
Band2p14Start65,310,851 bp[1]
End65,432,637 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SPRED2
Genomic location for SPRED2
Band11|11 A3.1Start19,874,375 bp[2]
End19,974,026 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • mucosa of sigmoid colon

  • ventricular zone

  • cartilage tissue

  • epithelium of colon

  • gonad

  • postcentral gyrus

  • prefrontal cortex

  • superior frontal gyrus

  • Brodmann area 46
Top expressed in
  • tail of embryo

  • primitive streak

  • prefrontal cortex

  • cingulate gyrus

  • genital tubercle

  • hair follicle

  • primary motor cortex

  • hippocampus proper

  • cerebellar vermis

  • lobe of cerebellum
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein kinase binding
  • protein serine/threonine kinase inhibitor activity
  • stem cell factor receptor binding
Cellular component
  • cytoplasm
  • plasma membrane
  • transport vesicle membrane
  • membrane
  • cytoplasmic vesicle
  • cytosol
Biological process
  • multicellular organism development
  • negative regulation of peptidyl-threonine phosphorylation
  • regulation of signal transduction
  • fibroblast growth factor receptor signaling pathway
  • regulation of protein deacetylation
  • positive regulation of DNA damage response, signal transduction by p53 class mediator
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

200734

114716

Ensembl

ENSG00000198369

ENSMUSG00000045671

UniProt

Q7Z698

Q924S7

RefSeq (mRNA)

NM_001128210
NM_181784

NM_033523

RefSeq (protein)

NP_001121682
NP_861449

NP_277058

Location (UCSC)Chr 2: 65.31 – 65.43 MbChr 11: 19.87 – 19.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.[5]

Function

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1[5]).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198369 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045671 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Wakioka T, Sasaki A, Kato R, et al. (2001). "Spred is a Sprouty-related suppressor of Ras signalling". Nature. 412 (6847): 647–51. Bibcode:2001Natur.412..647W. doi:10.1038/35088082. PMID 11493923. S2CID 4345140.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kato R, Nonami A, Taketomi T, et al. (2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochem. Biophys. Res. Commun. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Nobuhisa I, Kato R, Inoue H, et al. (2004). "Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation". J. Exp. Med. 199 (5): 737–42. doi:10.1084/jem.20030830. PMC 2213301. PMID 14981116.
  • Miyoshi K, Wakioka T, Nishinakamura H, et al. (2004). "The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization". Oncogene. 23 (33): 5567–76. doi:10.1038/sj.onc.1207759. PMID 15184877.
  • Zimmermann J, Jarchau T, Walter U, et al. (2005). "1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain". J. Biomol. NMR. 29 (3): 435–6. doi:10.1023/B:JNMR.0000032526.17586.8c. PMID 15213456. S2CID 37933714.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Engelhardt CM, Bundschu K, Messerschmitt M, et al. (2005). "Expression and subcellular localization of Spred proteins in mouse and human tissues". Histochem. Cell Biol. 122 (6): 527–38. doi:10.1007/s00418-004-0725-6. PMID 15580519. S2CID 24496085.
  • King JA, Straffon AF, D'Abaco GM, et al. (2005). "Distinct requirements for the Sprouty domain for functional activity of Spred proteins". Biochem. J. 388 (Pt 2): 445–54. doi:10.1042/BJ20041284. PMC 1138951. PMID 15683364.
  • Bundschu K, Knobeloch KP, Ullrich M, et al. (2005). "Gene disruption of Spred-2 causes dwarfism". J. Biol. Chem. 280 (31): 28572–80. doi:10.1074/jbc.M503640200. PMID 15946934.
  • Yoshida T, Hisamoto T, Akiba J, et al. (2006). "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors". Oncogene. 25 (45): 6056–66. doi:10.1038/sj.onc.1209635. PMID 16652141.
  • Lock P, I ST, Straffon AF, et al. (2007). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochem. Biophys. Res. Commun. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.
  • GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1
  • v
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  • 2jp2: Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)
    2jp2: Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)


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