SUDS3

Protein-coding gene in the species Homo sapiens
SUDS3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2N2H, 4ZQA

Identifiers
AliasesSUDS3, SAP45, SDS3, SDS3 homolog, SIN3A corepressor complex component
External IDsOMIM: 608250; MGI: 1919204; HomoloGene: 15906; GeneCards: SUDS3; OMA:SUDS3 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SUDS3
Genomic location for SUDS3
Band12q24.23Start118,376,555 bp[1]
End118,418,033 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SUDS3
Genomic location for SUDS3
Band5|5 FStart117,229,745 bp[2]
End117,254,178 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • buccal mucosa cell

  • palpebral conjunctiva

  • pancreatic epithelial cell

  • epithelium of colon

  • parotid gland

  • skin of arm

  • tonsil

  • germinal epithelium

  • bone marrow cells
Top expressed in
  • spermatid

  • spermatocyte

  • saccule

  • neural layer of retina

  • blood

  • otic placode

  • otic vesicle

  • granulocyte

  • lens

  • lip
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • histone deacetylase binding
  • protein binding
  • enzyme binding
  • histone deacetylase activity
Cellular component
  • Sin3 complex
  • nucleoplasm
  • Sin3-type complex
  • nucleus
  • cytosol
  • nuclear body
Biological process
  • regulation of transcription, DNA-templated
  • substantia nigra development
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • positive regulation of apoptotic process
  • negative regulation of transcription, DNA-templated
  • histone deacetylation
  • apoptotic process
  • protein deubiquitination
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64426

71954

Ensembl

ENSG00000111707

ENSMUSG00000066900

UniProt

Q9H7L9

Q8BR65

RefSeq (mRNA)

NM_022491

NM_001122666
NM_178622

RefSeq (protein)

NP_071936

NP_001116138
NP_848737

Location (UCSC)Chr 12: 118.38 – 118.42 MbChr 5: 117.23 – 117.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.[5][6]

Function

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM][6]

Interactions

SUDS3 has been shown to interact with HDAC1,[5][7] Host cell factor C1,[8] SIN3B[5] and SIN3A.[5][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111707 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066900 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (April 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
  6. ^ a b "Entrez Gene: SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)".
  7. ^ a b Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
  8. ^ Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
  • Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
  • Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (December 2000). "Characterization of long cDNA clones from human adult spleen". DNA Research. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
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