SUPT7L

Protein-coding gene in the species Homo sapiens
SUPT7L
Identifiers
AliasesSUPT7L, SPT7L, STAF65, STAF65(gamma), STAF65G, SUPT7H, SPT7-like STAGA complex gamma subunit, SPT7 like, STAGA complex gamma subunit, SPT7 like, STAGA complex subunit gamma
External IDsOMIM: 612762; MGI: 1919445; HomoloGene: 8907; GeneCards: SUPT7L; OMA:SUPT7L - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SUPT7L
Genomic location for SUPT7L
Band2p23.3Start27,650,809 bp[1]
End27,663,840 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SUPT7L
Genomic location for SUPT7L
Band5|5 B1Start31,671,908 bp[2]
End31,685,151 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • right uterine tube

  • anterior pituitary

  • right hemisphere of cerebellum

  • left ovary

  • apex of heart

  • right ovary

  • granulocyte

  • right lobe of thyroid gland

  • right frontal lobe
Top expressed in
  • Rostral migratory stream

  • zygote

  • secondary oocyte

  • tail of embryo

  • ventricular zone

  • genital tubercle

  • aortic valve

  • cumulus cell

  • ascending aorta

  • proximal tubule
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • transcription coactivator activity
  • protein binding
  • histone acetyltransferase activity
  • protein heterodimerization activity
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription, DNA-templated
  • maintenance of protein location in nucleus
  • histone H3 acetylation
  • transcription, DNA-templated
  • positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9913

72195

Ensembl

ENSG00000119760

ENSMUSG00000053134

UniProt

O94864

Q9CZV5

RefSeq (mRNA)

NM_001282729
NM_001282730
NM_001282731
NM_001282732
NM_014860

NM_028150

RefSeq (protein)

NP_001269658
NP_001269659
NP_001269660
NP_001269661
NP_055675

NP_082426

Location (UCSC)Chr 2: 27.65 – 27.66 MbChr 5: 31.67 – 31.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

STAGA complex 65 subunit gamma is a protein that in humans is encoded by the SUPT7L gene.[5][6][7]

Interactions

SUPT7L has been shown to interact with TAF9[6] and Transcription initiation protein SPT3 homolog.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119760 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053134 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ a b c Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
  7. ^ "Entrez Gene: SUPT7L suppressor of Ty 7 (S. cerevisiae)-like".

Further reading

  • Nishizaka S, Gomi S, Harada K, Oizumi K, Itoh K, Shichijo S (September 2000). "A new tumor-rejection antigen recognized by cytotoxic T lymphocytes infiltrating into a lung adenocarcinoma". Cancer Research. 60 (17): 4830–7. PMID 10987294.
  • Gocke CB, Yu H, Kang J (February 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.
  • Wang HY, Peng G, Guo Z, Shevach EM, Wang RF (March 2005). "Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells". Journal of Immunology. 174 (5): 2661–70. doi:10.4049/jimmunol.174.5.2661. PMID 15728473.
  • Soutoglou E, Demény MA, Scheer E, Fienga G, Sassone-Corsi P, Tora L (May 2005). "The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners". Molecular and Cellular Biology. 25 (10): 4092–104. doi:10.1128/MCB.25.10.4092-4104.2005. PMC 1087738. PMID 15870280.
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