TH-030418
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IUPAC name 7α-[(R)-1-hydroxy-1-methyl-3-(thiophen-3-yl)-propyl]-6,14-endo-ethanotetrahydrooripavine | |
Identifiers | |
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3D model (JSmol) |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
TH-030418 is an extremely potent opioid related to thienorphine. TH-030418 about 5000 times more potent than morphine.[1][2]
See also
- BU72
- Dihydroetorphine
- Etorphine (M99)
- M320
References
- ^ Yu, G; Yan, LD; Li, YL; Wen, Q; Dong, HJ; Gong, ZH (August 2011). "TH-030418: a potent long-acting opioid analgesic with low dependence liability". Naunyn-Schmiedeberg's Archives of Pharmacology. 384 (2): 125–31. doi:10.1007/s00210-011-0652-8. PMID 21594658.
- ^ Wen, Q; Yu, G; Li, YL; Yan, LD; Gong, ZH (October 2011). "Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 6,14-bridged oripavine compound 030418". Acta Pharmacologica Sinica. 32 (10): 1215–24. doi:10.1038/aps.2011.83. PMC 4010084. PMID 21863064.
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Opioid receptor modulators
(MOR)
(DOR)
(KOR)
(NOP)
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Antagonists |
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- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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