TRAK1

Protein-coding gene in the species Homo sapiens
TRAK1
Identifiers
AliasesTRAK1, MILT1, OIP106, trafficking kinesin protein 1, EIEE68, DEE68
External IDsOMIM: 608112; MGI: 1914345; HomoloGene: 25103; GeneCards: TRAK1; OMA:TRAK1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TRAK1
Genomic location for TRAK1
Band3p22.1Start42,013,802 bp[1]
End42,225,890 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for TRAK1
Genomic location for TRAK1
Band9 F4|9 72.41 cMStart121,126,568 bp[2]
End121,303,984 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • paraflocculus of cerebellum

  • muscle of thigh

  • epithelium of bronchus

  • pylorus

  • bronchial epithelial cell

  • right auricle

  • epithelium of nasopharynx

  • nipple

  • frontal pole
Top expressed in
  • aortic valve

  • ascending aorta

  • muscle of thigh

  • myocardium of ventricle

  • superior frontal gyrus

  • zygote

  • ankle joint

  • dentate gyrus of hippocampal formation granule cell

  • stria vascularis

  • lip
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • GABA receptor binding
  • TPR domain binding
  • signaling receptor binding
  • myosin binding
Cellular component
  • cytoplasm
  • endosome
  • early endosome
  • mitochondrion
  • nucleus
  • axon cytoplasm
  • dendrite
  • axonal growth cone
  • perinuclear region of cytoplasm
  • cytoplasmic vesicle
  • dendrite cytoplasm
  • cell cortex
  • membrane
  • mitochondrial membranes
Biological process
  • regulation of transcription by RNA polymerase II
  • protein targeting
  • protein O-linked glycosylation
  • endosome to lysosome transport
  • anterograde axonal transport of mitochondrion
  • axonal transport of mitochondrion
  • dendrite morphogenesis
  • positive regulation of axonogenesis
  • anterograde axonal transport
  • protein localization
  • neurogenesis
  • vesicle transport along microtubule
  • mitochondrion distribution
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22906

67095

Ensembl

ENSG00000182606

ENSMUSG00000032536

UniProt

Q9UPV9

Q6PD31

RefSeq (mRNA)
NM_001042646
NM_001265608
NM_001265609
NM_001265610
NM_014965

NM_001349245
NM_001349246
NM_001349247
NM_001349248
NM_001349249

NM_175114
NM_001357968
NM_001357969
NM_001357970
NM_001357972

NM_001357973

RefSeq (protein)
NP_001036111
NP_001252537
NP_001252538
NP_001252539
NP_055780

NP_001336174
NP_001336175
NP_001336176
NP_001336177
NP_001336178

NP_780323
NP_001344897
NP_001344898
NP_001344899
NP_001344901

NP_001344902

Location (UCSC)Chr 3: 42.01 – 42.23 MbChr 9: 121.13 – 121.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trafficking kinesin-binding protein 1 is a protein that in humans is encoded by the TRAK1 gene.[5][6][7][8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182606 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032536 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  6. ^ Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J Biol Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
  7. ^ Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Jan 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nat Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.
  8. ^ "Entrez Gene: TRAK1 trafficking protein, kinesin binding 1".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Iyer SP, Hart GW (2003). "Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity". J. Biol. Chem. 278 (27): 24608–16. doi:10.1074/jbc.M300036200. PMID 12724313.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
  • Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. CiteSeerX 10.1.1.123.3574. doi:10.1167/iovs.04-1380. PMID 15851553.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.


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