TRIM45

Protein-coding gene in the species Homo sapiens
TRIM45
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DS4

Identifiers
AliasesTRIM45, RNF99, tripartite motif containing 45
External IDsOMIM: 609318; MGI: 1918187; HomoloGene: 11865; GeneCards: TRIM45; OMA:TRIM45 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TRIM45
Genomic location for TRIM45
Band1p13.1Start117,111,060 bp[1]
End117,122,587 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for TRIM45
Genomic location for TRIM45
Band3|3 F2.2Start100,829,518 bp[2]
End100,844,236 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • right uterine tube

  • apex of heart

  • testicle

  • muscle of thigh

  • gastrocnemius muscle

  • right auricle

  • gonad

  • tibialis anterior muscle

  • deltoid muscle
Top expressed in
  • otolith organ

  • utricle

  • vestibular sensory epithelium

  • olfactory system

  • olfactory epithelium

  • seminiferous tubule

  • internal carotid artery

  • external carotid artery

  • spermatid

  • Jacobson's organ
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
Cellular component
  • intracellular anatomical structure
  • nucleus
  • nucleoplasm
  • intercellular bridge
  • cytoplasm
  • cytosol
Biological process
  • bone development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80263

229644

Ensembl

ENSG00000134253

ENSMUSG00000033233

UniProt

Q9H8W5

Q6PFY8

RefSeq (mRNA)

NM_001145635
NM_025188

NM_001165952
NM_001165953
NM_194343

RefSeq (protein)

NP_001139107
NP_079464

NP_001159424
NP_001159425
NP_919324

Location (UCSC)Chr 1: 117.11 – 117.12 MbChr 3: 100.83 – 100.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tripartite motif containing 45, also known as TRIM45, is a human gene.[5]

This gene encodes a member of the tripartite motif family. The encoded protein may function as a [transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134253 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033233 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: tripartite motif containing 45". Retrieved 2011-08-30.

Further reading

  • Sardiello M, Cairo S, Fontanella B, Ballabio A, Meroni G (2008). "Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties". BMC Evolutionary Biology. 8 (1): 225. Bibcode:2008BMCEE...8..225S. doi:10.1186/1471-2148-8-225. PMC 2533329. PMID 18673550.
  • Wang Y, Li Y, Qi X, Yuan W, Ai J, Zhu C, Cao L, Yang H, Liu F, Wu X, Liu M (Oct 2004). "TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1". Biochemical and Biophysical Research Communications. 323 (1): 9–16. doi:10.1016/j.bbrc.2004.08.048. PMID 15351693.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.