TRIM55

Protein-coding gene in the species Homo sapiens

TRIM55
Identifiers
AliasesTRIM55, MURF-2, RNF29, muRF2, tripartite motif containing 55
External IDsOMIM: 606469; MGI: 3036269; HomoloGene: 13205; GeneCards: TRIM55; OMA:TRIM55 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for TRIM55
Genomic location for TRIM55
Band8q13.1Start66,126,896 bp[1]
End66,175,485 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for TRIM55
Genomic location for TRIM55
Band3|3 A2Start19,698,638 bp[2]
End19,746,585 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right auricle

  • myocardium of left ventricle

  • cardiac muscle tissue of right atrium

  • apex of heart

  • muscle of thigh

  • deltoid muscle

  • tibialis anterior muscle

  • right lobe of liver

  • gastrocnemius muscle

  • biceps brachii
Top expressed in
  • heart

  • skeletal muscle tissue

  • quadriceps femoris muscle

  • muscle of thigh

  • esophagus

  • embryo

  • zone of skin

  • lip

  • lens

  • neural tube
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • zinc ion binding
  • protein binding
  • signal transducer activity
  • metal ion binding
  • identical protein binding
Cellular component
  • cytoplasm
  • microtubule
  • intracellular anatomical structure
  • nucleus
Biological process
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84675

381485

Ensembl

ENSG00000147573

ENSMUSG00000060913

UniProt

Q9BYV6

G3X8Y1

RefSeq (mRNA)

NM_033058
NM_184085
NM_184086
NM_184087

NM_001081281

RefSeq (protein)

NP_149047
NP_908973
NP_908974
NP_908975

NP_001074750

Location (UCSC)Chr 8: 66.13 – 66.18 MbChr 3: 19.7 – 19.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene.[5][6]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147573 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060913 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol. 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782.
  6. ^ a b "Entrez Gene: TRIM55 tripartite motif-containing 55".

Further reading

  • McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.
  • Pizon V, Iakovenko A, Van Der Ven PF, et al. (2003). "Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein". J. Cell Sci. 115 (Pt 23): 4469–82. doi:10.1242/jcs.00131. PMID 12414993. S2CID 16068484.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods. 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160. S2CID 6135437.
  • Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science. 308 (5728): 1599–603. CiteSeerX 10.1.1.383.9888. doi:10.1126/science.1110463. PMID 15802564. S2CID 2809403.
  • Witt SH, Granzier H, Witt CC, Labeit S (2005). "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination". J. Mol. Biol. 350 (4): 713–22. doi:10.1016/j.jmb.2005.05.021. PMID 15967462.


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