Protein-coding gene in the species Homo sapiens
| TRIM6 |
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| Identifiers |
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| Aliases | TRIM6, RNF89, tripartite motif containing 6 |
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| External IDs | OMIM: 607564; MGI: 2137352; HomoloGene: 14381; GeneCards: TRIM6; OMA:TRIM6 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 11 (human)[1] |
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| | Band | 11p15.4 | Start | 5,596,109 bp[1] |
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| End | 5,612,958 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7 E3|7 55.55 cM | Start | 103,868,000 bp[2] |
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| End | 103,884,359 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - oocyte
- secondary oocyte
- gonad
- human kidney
- parotid gland
- palpebral conjunctiva
- germinal epithelium
- tibia
- testicle
- parietal pleura
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| | Top expressed in | - yolk sac
- morula
- blastocyst
- embryo
- epiblast
- primitive streak
- spermatocyte
- embryo
- tail of embryo
- secondary oocyte
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - protein-macromolecule adaptor activity
- protein tyrosine kinase binding
- ubiquitin protein ligase activity
- zinc ion binding
- transcription factor binding
- metal ion binding
- protein binding
- protein kinase binding
- transferase activity
| | Cellular component | - cytoplasm
- cytosol
- intracellular anatomical structure
- nucleus
| | Biological process | - positive regulation of transcription regulatory region DNA binding
- cellular response to virus
- positive regulation of type I interferon-mediated signaling pathway
- regulation of NIK/NF-kappaB signaling
- free ubiquitin chain polymerization
- cellular response to interferon-beta
- protein trimerization
- protein polyubiquitination
- negative regulation of gene expression
- positive regulation of peptidyl-serine phosphorylation
- negative regulation of stem cell differentiation
- response to lipopolysaccharide
- negative regulation of viral genome replication
- positive regulation of gene expression
- positive regulation of peptidyl-threonine phosphorylation
- protein ubiquitination
- negative regulation of transcription, DNA-templated
- positive regulation of defense response to virus by host
- viral process
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_058166
NM_001003818
NM_001198644
NM_001198645 |
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| RefSeq (protein) | |
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NP_001003818
NP_001185573
NP_001185574
NP_477514 |
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| Location (UCSC) | Chr 11: 5.6 – 5.61 Mb | Chr 7: 103.87 – 103.88 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.[5][6]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000121236 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072244 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
- ^ a b "Entrez Gene: TRIM6 tripartite motif-containing 6".
Further reading
- Li X, Gold B, O'hUigin C, et al. (2007). "Unique features of TRIM5alpha among closely related human TRIM family members". Virology. 360 (2): 419–33. doi:10.1016/j.virol.2006.10.035. PMID 17156811.
- Zhang F, Hatziioannou T, Perez-Caballero D, et al. (2006). "Antiretroviral potential of human tripartite motif-5 and related proteins". Virology. 353 (2): 396–409. doi:10.1016/j.virol.2006.05.035. PMID 16828831.
- Li X, Li Y, Stremlau M, et al. (2006). "Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains". J. Virol. 80 (13): 6198–206. doi:10.1128/JVI.00283-06. PMC 1488960. PMID 16775307.
- Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Orimo A, Tominaga N, Yoshimura K, et al. (2001). "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem". Genomics. 69 (1): 143–9. doi:10.1006/geno.2000.6318. PMID 11013086.
