Protein-coding gene in the species Homo sapiens
EIPR1 |
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Identifiers |
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Aliases | EIPR1, TSSC1, tumor suppressing subtransferable candidate 1, EIPR-1, EARP complex and GARP complex interacting protein 1 |
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External IDs | OMIM: 608998; MGI: 1289332; HomoloGene: 2481; GeneCards: EIPR1; OMA:EIPR1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2p25.3 | Start | 3,188,925 bp[1] |
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End | 3,377,830 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 12 (mouse)[2] |
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| Band | 12 A2|12 11.26 cM | Start | 28,801,802 bp[2] |
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End | 28,919,864 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - prefrontal cortex
- anterior pituitary
- nucleus accumbens
- anterior cingulate cortex
- right frontal lobe
- putamen
- Brodmann area 9
- caudate nucleus
- oocyte
- olfactory zone of nasal mucosa
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| Top expressed in | - dentate gyrus of hippocampal formation granule cell
- yolk sac
- superior frontal gyrus
- morula
- embryo
- blood
- right kidney
- embryo
- primary visual cortex
- neural tube
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| More reference expression data |
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BioGPS | | More reference expression data |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_003310 NM_001330530 NM_001330531 |
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NM_201357 NM_001379229 NM_001379230 |
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RefSeq (protein) | |
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NP_001317459 NP_001317460 NP_003301 |
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NP_958745 NP_001366158 NP_001366159 NP_001390093 NP_001390094 |
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Location (UCSC) | Chr 2: 3.19 – 3.38 Mb | Chr 12: 28.8 – 28.92 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Protein TSSC1 is a protein that in humans is encoded by the TSSC1 gene.[5][6][7]
Function
This gene has been reported[8] as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene may reside on chromosome 2 rather than chromosome 11.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000032389 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036613 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hu RJ, Lee MP, Connors TD, Johnson LA, Burn TC, Su K, Landes GM, Feinberg AP (November 1997). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.
- ^ Scelfo R, Sabbioni S, Barbanti-Brodano G, Negrini M (Mar 1999). "Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster". Cytogenetics and Cell Genetics. 83 (1–2): 52–3. doi:10.1159/000015123. PMID 9925925. S2CID 9646786.
- ^ a b "Entrez Gene: TSSC1 tumor suppressing subtransferable candidate 1".
- ^ Hu RJ, Lee MP, Connors TD, et al. (November 1997). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.
Further reading
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.