Terizidone
Chemical compound
- C
- J04AK03 (WHO)
- 4,4'-{1,4-Phenylenebis[(E)methylylidene
(E)azanylylidene]}bis(1,2-oxazolidin-3-one)
- 25683-71-0 N
- 65720
- 59144 Y
- 1199LEX5N8
- D07247 Y
- DTXSID70905098
- Interactive image
- O=C3NOCC3/N=C/c2ccc(/C=N/C1C(=O)NOC1)cc2
InChI
- InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+ Y
- Key:ODKYYBOHSVLGNU-IAGONARPSA-N Y
Terizidone is a drug used in the treatment of tuberculosis.[1] Terizidone is mainly used in multi-drug-resistant tuberculosis (MDR-TB) in conjunction with other second-line drugs. It is a derivate of cycloserine and it is bacteriostatic.[2]
References
- ^ Galietti F, Giorgis GE, Oliaro A, Boaro D, Ardizzi A, Barberis S, Massaglia GM (1991). "[Tolerability to terizidone (TZ) in the treatment of pulmonary tuberculosis in dialyzed patients]". Minerva Medica. 82 (7–8): 477–81. PMID 1922892.
- ^ Rossiter D (2012). South African Medicines Formulary. Cape Town, South Africa: Health and Medical Publishing Group of the South African Medical Association. pp. 323–325. ISBN 978-1-875098-28-6.
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Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
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ASA | |
Topoisomerase inhibitors/ quinolones |
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Arabinogalactan layer |
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Mycolic acid layer |
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- Phenazine (Clofazimine)#
- Pyrazine (Pyrazinamide#, Morinamide)
- Isoxazole (Terizidone)
- Bedaquiline
- Nitroimidazole (Delamanid, Pretomanid)
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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