WRNIP1

Protein-coding gene in the species Homo sapiens
WRNIP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3VHS, 3VHT

Identifiers
AliasesWRNIP1, WHIP, bA420G6.2, Werner helicase interacting protein 1, WRN helicase interacting protein 1, CFAP93, FAP93
External IDsOMIM: 608196; MGI: 1926153; HomoloGene: 10592; GeneCards: WRNIP1; OMA:WRNIP1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for WRNIP1
Genomic location for WRNIP1
Band6p25.2Start2,765,393 bp[1]
End2,786,952 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for WRNIP1
Genomic location for WRNIP1
Band13|13 A3.2Start32,986,021 bp[2]
End33,006,592 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • skin of arm

  • internal globus pallidus

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • anterior pituitary

  • ventricular zone

  • cerebellar vermis

  • body of pancreas

  • myocardium of left ventricle
Top expressed in
  • habenula

  • vestibular membrane of cochlear duct

  • ventromedial nucleus

  • supraoptic nucleus

  • dentate gyrus of hippocampal formation granule cell

  • Paneth cell

  • dorsomedial hypothalamic nucleus

  • Gonadal ridge

  • endocardial cushion

  • anterior amygdaloid area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • nucleotide binding
  • ATPase activity
  • protein binding
  • hydrolase activity
  • ATP binding
  • metal ion binding
  • identical protein binding
  • enzyme activator activity
  • single-stranded DNA helicase activity
Cellular component
  • perinuclear region of cytoplasm
  • membrane
  • nucleus
  • cytoplasm
  • replisome
Biological process
  • DNA replication
  • DNA synthesis involved in DNA repair
  • regulation of DNA-dependent DNA replication initiation
  • DNA repair
  • cellular response to DNA damage stimulus
  • immune system process
  • DNA-dependent DNA replication
  • regulation of DNA repair
  • DNA recombination
  • DNA replication, Okazaki fragment processing
  • positive regulation of catalytic activity
  • innate immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56897

78903

Ensembl

ENSG00000124535

ENSMUSG00000021400

UniProt

Q96S55

Q91XU0

RefSeq (mRNA)

NM_020135
NM_130395

NM_030215

RefSeq (protein)

NP_064520
NP_569079

NP_084491

Location (UCSC)Chr 6: 2.77 – 2.79 MbChr 13: 32.99 – 33.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATPase WRNIP1 is an enzyme that is encoded by the WRNIP1 gene in humans.[5][6] The protein is a member of AAA ATPase family.

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.[6]

Interactions

WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124535 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021400 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T (Jun 2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem. 276 (23): 20364–9. doi:10.1074/jbc.C100035200. PMID 11301316.
  6. ^ a b "Entrez Gene: WRNIP1 Werner helicase interacting protein 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. S2CID 24977510.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Bish RA, Myers MP (2007). "Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain". J. Biol. Chem. 282 (32): 23184–93. doi:10.1074/jbc.M701042200. PMID 17550899.

External links


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