CXCL8 |
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Structure de la solution de l'IL-8 telle que publiée dans la Protein Data Bank |
Structures disponibles |
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PDB | Recherche UniProt humaine: PDBe RCSB |
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Identifiants PDB |
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3IL8, 1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 4XDX |
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Identifiants |
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Aliases | CXCL8, Interleukine 8, CX-CL8 |
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IDs externes | OMIM: 146930 HomoloGene: 47937 GeneCards: CXCL8 |
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Position du gène (Homme) |
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| Chr. | Chromosome 4 humain[1] |
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| Locus | 4q13.3 | Début | 73,740,519 bp[1] |
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Fin | 73,743,716 bp[1] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - ligament alvéolo-dentaire
- granulocyte
- cellule bêta
- cartilage tissue
- olfactory zone of nasal mucosa
- monocyte
- mucosa of paranasal sinus
- cellule de la moelle osseuse
- sperme
- vésicule biliaire
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| | Plus de données d'expression de référence |
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BioGPS |
| Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - cytokine activity
- liaison protéique
- interleukin-8 receptor binding
- chemokine activity
| Composant cellulaire | - région extracellulaire
- intracellulaire
- milieu extracellulaire
| Processus biologique | - G protein-coupled receptor signaling pathway
- intracellular signal transduction
- chemokine-mediated signaling pathway
- cellular response to tumor necrosis factor
- internalisation de récepteur
- cellular response to fibroblast growth factor stimulus
- response to endoplasmic reticulum stress
- positive regulation of angiogenesis
- regulation of single stranded viral RNA replication via double stranded DNA intermediate
- PERK-mediated unfolded protein response
- induction of positive chemotaxis
- chimiotaxie
- regulation of cell adhesion
- réponse immunitaire
- cellular response to interleukin-1
- angiogenèse
- positive regulation of neutrophil chemotaxis
- réponse inflammatoire
- negative regulation of G protein-coupled receptor signaling pathway
- response to molecule of bacterial origin
- cellular response to lipopolysaccharide
- embryonic digestive tract development
- transduction de signal
- negative regulation of cell population proliferation
- calcium-mediated signaling
- regulation of entry of bacterium into host cell
- réponse de défense
- neutrophil chemotaxis
- neutrophil activation
- antimicrobial humoral immune response mediated by antimicrobial peptide
- regulation of signaling receptor activity
- cytokine-mediated signaling pathway
- leukocyte chemotaxis
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protéine) | | |
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Localisation (UCSC) | Chr 4: 73.74 – 73.74 Mb | n/a |
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Publication PubMed | [2] | n/a |
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Wikidata |
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