SMAD7 |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ |
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Identifiants |
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Aliases | SMAD7 |
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IDs externes | OMIM: 602932 MGI: 1100518 HomoloGene: 4314 GeneCards: SMAD7 |
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Position du gène (Homme) |
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| Chr. | Chromosome 18 humain[1] |
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| Locus | 18q21.1 | Début | 48,919,853 bp[1] |
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Fin | 48,950,965 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 18 (souris)[2] |
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| Locus | 18|18 E3 | Début | 75,500,600 bp[2] |
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Fin | 75,529,006 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - artère poplitée
- Tibial arteries
- Veine saphène
- Descending thoracic aorta
- auricule droit
- aorte ascendante
- cardiac muscle tissue of right atrium
- poumon droit
- artère coronaire gauche
- artère coronaire droite
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| Fortement exprimé dans | - molaire
- gastrula
- left lung lobe
- antre du pylore
- crête génitale
- Caduque basale
- cumulus cell
- lumbar subsegment of spinal cord
- substantia nigra
- sang
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| Plus de données d'expression de référence |
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BioGPS | | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison ADN
- beta-catenin binding
- type I transforming growth factor beta receptor binding
- collagen binding
- I-SMAD binding
- activin binding
- DNA-binding transcription factor activity
- liaison ion métal
- liaison protéique
- ubiquitin protein ligase binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Composant cellulaire | - cytoplasme
- centrosome
- transcription regulator complex
- membrane plasmique
- intracellulaire
- nucléoplasme
- catenin complex
- noyau
- fibrillar center
- cytosol
- complexe macromoléculaire
| Processus biologique | - cellular response to transforming growth factor beta stimulus
- regulation of ventricular cardiac muscle cell membrane depolarization
- pathway-restricted SMAD protein phosphorylation
- ureteric bud development
- regulation of transcription, DNA-templated
- adherens junction assembly
- positive regulation of cell-cell adhesion
- ventricular septum morphogenesis
- regulation of epithelial to mesenchymal transition
- negative regulation of peptidyl-threonine phosphorylation
- negative regulation of transcription by competitive promoter binding
- response to laminar fluid shear stress
- protein stabilization
- regulation of activin receptor signaling pathway
- negative regulation of transcription by RNA polymerase II
- negative regulation of transforming growth factor beta receptor signaling pathway
- BMP signaling pathway
- negative regulation of DNA-binding transcription factor activity
- negative regulation of pathway-restricted SMAD protein phosphorylation
- negative regulation of BMP signaling pathway
- ventricular cardiac muscle tissue morphogenesis
- negative regulation of protein ubiquitination
- negative regulation of cell migration
- negative regulation of ubiquitin-protein transferase activity
- artery morphogenesis
- negative regulation of peptidyl-serine phosphorylation
- regulation of cardiac muscle contraction
- positive regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of epithelial to mesenchymal transition
- positive regulation of transcription by RNA polymerase II
- regulation of transforming growth factor beta receptor signaling pathway
- transcription, DNA-templated
- transforming growth factor beta receptor signaling pathway
- protein deubiquitination
- negative regulation of T cell cytokine production
- negative regulation of T-helper 17 type immune response
- negative regulation of T-helper 17 cell differentiation
- cellular response to leukemia inhibitory factor
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_005904 NM_001190821 NM_001190822 NM_001190823 |
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RefSeq (protéine) | |
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NP_001177750 NP_001177751 NP_001177752 NP_005895 |
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Localisation (UCSC) | Chr 18: 48.92 – 48.95 Mb | Chr 18: 75.5 – 75.53 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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