Angiotenzin
edit |
Angiotenzin (inhibitor seprin peptidaze, klasa A, član 8) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Modeli angiotenzina I (levo) i II (desno) iz PDB 1N9U i PDB 1N9V. | |||||||||||
Identifikatori | |||||||||||
Simboli | AGT; ANHU; SERPINA8 | ||||||||||
Vanjski ID | OMIM: 106150 MGI: 87963 HomoloGene: 14 GeneCards: AGT Gene | ||||||||||
| |||||||||||
Pregled RNK izražavanja | |||||||||||
podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 183 | 11606 | |||||||||
Ensembl | ENSG00000135744 | ENSMUSG00000031980 | |||||||||
UniProt | P01019 | Q3UTR7 | |||||||||
Ref. Sekv. (iRNK) | NM_000029 | NM_007428 | |||||||||
Ref. Sekv. (protein) | NP_000020 | NP_031454 | |||||||||
Lokacija (UCSC) | Chr 1: 228.9 - 228.92 Mb | Chr 8: 127.44 - 127.46 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Angiotenzin je protein koji se pod uticajem enzima renina daje angiotenzin I, čije se proteinsko tijelo sastoji od 10 aminokiselina.[1]
Angiotenzin se proizvodi u jetri, a cirkuliše u krvnoj plazmi čovjeka. On je bitan faktor kod regulacije krvnog pritiska, jer je direktni činilac sistema renin-angiotenzin-aldosteron (RAAS).[2]
Kod čovjeka, angiotenzin se sastoji iz 485 aminokiselina. NJegov gen leži na dugom kraku hromozoma 1.
Reference
Literatura
- de Gasparo M, Catt KJ, Inagami T, "et al." (2000). „International union of pharmacology. XXIII. The angiotensin II receptors”. Parmacol Rev. 52 (3): 415-472. PMID 10977869.
- Brenner & Rector's The Kidney, 7th ed., Saunders, 2004.
- Mosby's Medical Dictionary, 3rd Ed., CV Mosby Company, 1990.
- Review of Medical Physiology, 20th Ed., William F. Ganong, McGraw-Hill, 2001.
- Clinical Physiology of Acid-Base and Electrolyte Disorders, 5th ed., Burton David Rose & Theodore W. Post McGraw-Hill, 2001
- Lees KR, MacFadyen RJ, Doig JK, Reid JL (1993). „Role of angiotensin in the extravascular system”. Journal of human hypertension 7 Suppl 2: S7–12. PMID 8230088.
- Weir MR, Dzau VJ (2000). „The renin-angiotensin-aldosterone system: a specific target for hypertension management”. Am. J. Hypertens. 12 (12 Pt 3): 205S–213S. DOI:10.1016/S0895-7061(99)00103-X. PMID 10619573.
- Berry C, Touyz R, Dominiczak AF, et al. (2002). „Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide”. Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400.
- Sernia C (2002). „A critical appraisal of the intrinsic pancreatic angiotensin-generating system”. JOP 2 (1): 50-5. PMID 11862023.
- Varagic J, Frohlich ED (2003). „Local cardiac renin-angiotensin system: hypertension and cardiac failure”. J. Mol. Cell. Cardiol. 34 (11): 1435-42. DOI:10.1006/jmcc.2002.2075. PMID 12431442.
- Wolf G (2006). „Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis”. Antioxid. Redox Signal. 7 (9-10): 1337-45. DOI:10.1089/ars.2005.7.1337. PMID 16115039.
- Cazaubon S, Deshayes F, Couraud PO, Nahmias C (2006). „[Endothelin-1, angiotensin II and cancer]”. Med Sci (Paris) 22 (4): 416-22. PMID 16597412.
- Ariza AC, Bobadilla NA, Halhali A (2007). „[Endothelin 1 and angiotensin II in preeeclampsia]”. Rev. Invest. Clin. 59 (1): 48-56. PMID 17569300.
Spoljašnje veze
- Redoslijed baza u molekulu angiotenzinogena
- http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=19383
- p
- r
- u
vidi hormoni
Drugi |
---|
Kinini | |
---|---|
Neuromedini | |
Drugi | Angiotenzin • Bombezin • Peptid srodan kalcitoninu • Karnozin • Kokainom i amfetaminom regulisani transkript • Peptid indukovanja delta sna • FMRF amid • Galanin • Galaninu sličan peptid • Peptid oslobađanja gastrina • Neuropeptid S • Neuropeptid Y • Neurofizini • Neurotenzin • Pankreatični polipeptid • Aktivirajući peptid hipofizne adenilat ciklaze • RVD-Hpα • VGF |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)