Klatrin, laki polipeptid (Lca) |
Identifikatori |
Simbol | CLTA |
Entrez | 1211 |
HUGO | 2090 |
OMIM | 118960 |
RefSeq | NM_007096 |
UniProt | P09496 |
Drugi podaci |
Lokus | Hromozom 12 q23-q24 |
Klatrin, laki polipeptid (Lcb) |
Identifikatori |
Simbol | CLTB |
Entrez | 1212 |
HUGO | 2091 |
OMIM | 118970 |
RefSeq | NM_001834 |
UniProt | P09497 |
Drugi podaci |
Lokus | Hromozom 4 q |
Klatrin laki lanac Identifikatori |
Simbol | Clathrin_lg_ch |
Pfam | PF01086 |
InterPro | IPR000996 |
PROSITE | PDOC00196 |
Dostupne PDB strukture: | Pfam | structures | PDB | RCSB PDB; PDBe | PDBsum | strukturni pregled | |
Klatrin, teški polipeptid (Hc) |
Identifikatori |
Simbol | CLTC |
Alt. simboli | CLTCL2 |
Entrez | 1213 |
HUGO | 2092 |
OMIM | 118955 |
RefSeq | NM_004859 |
UniProt | Q00610 |
Drugi podaci |
Lokus | Hromozom 17 q11-qter |
Klatrin, teškom polipeptidu sličan 1 |
Identifikatori |
Simbol | CLTCL1 |
Alt. simboli | CLTCL |
Entrez | 8218 |
HUGO | 2093 |
OMIM | 601273 |
RefSeq | NM_001835 |
UniProt | P53675 |
Drugi podaci |
Lokus | Hromozom 22 q11.2 |
Klatrinsko propelersko ponavljanje |
terminalno domen klatrina u kompleksu sa tlpwdlwtt |
Identifikatori |
Simbol | Clathrin_propel |
Pfam | PF01394 |
Pfam klan | CL0020 |
InterPro | IPR022365 |
SCOP | 1bpo |
Superfamilija | 1bpo |
Dostupne PDB strukture: | Pfam | structures | PDB | RCSB PDB; PDBe | PDBsum | strukturni pregled | |
Veza klatrinskog teškog lanca |
Klatrinski terminalni domen u kompleksu sa tlpwdlwtt |
Identifikatori |
Simbol | Clathrin-link |
Pfam | PF09268 |
Pfam klan | CL0020 |
InterPro | IPR015348 |
SCOP | 1utc |
Superfamilija | 1utc |
Dostupne PDB strukture: | Pfam | structures | PDB | RCSB PDB; PDBe | PDBsum | strukturni pregled | |
Klatrin je protein koji ima centralnu ulogu u formiranju vezikula. Barbara Pears je prva izolovala i imenovala klatrin 1975.[1] On formira strukturu triskelionskog oblika koja se sastoji od tri klatrinska teška lanca i tri laka lanca. Kad se ove strukture slože nastaje polihedralna rešetka koja okružuje vezikulu. Pokrivajući proteini poput klatrina se koriste za formiranje malih vezikula kojima se molekuli mogu bezbedno trasportovati između ćelija. Endocitoza i egzocitoza vezikula omogućava ćelijama da razmenjuju nutrijente, da unose signalne receptore, da posreduju imunski respons nakon testiranja ekstracelularnog sveta, i uklanjaju ćelijski ostatke nakon zapaljenja tkiva. Povremeno ovaj mehanizam takođe služi kao način uklanjanja patogena ili toksina.
Reference
- ↑ Pearse BM (April 1976). „Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles”. Proceedings of the National Academy of Sciences of the United States of America 73 (4): 1255–9. DOI:10.1073/pnas.73.4.1255. PMC 430241. PMID 1063406.
Literatura
- Wakeham DE, Chen CY, Greene B, Hwang PK, Brodsky FM (October 2003). „Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation”. The EMBO Journal 22 (19): 4980–90. DOI:10.1093/emboj/cdg511. PMC 204494. PMID 14517237.
- Ford MG, Mills IG, Peter BJ, Vallis Y, Praefcke GJ, Evans PR, McMahon HT (September 2002). „Curvature of clathrin-coated pits driven by epsin”. Nature 419 (6905): 361–6. DOI:10.1038/nature01020. PMID 12353027.
- Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T (December 2004). „Molecular model for a complete clathrin lattice from electron cryomicroscopy”. Nature 432 (7017): 573–9. DOI:10.1038/nature03079. PMID 15502812.
- Mousavi SA, Malerød L, Berg T, Kjeken R (January 2004). „Clathrin-dependent endocytosis”. The Biochemical Journal 377 (Pt 1): 1–16. DOI:10.1042/BJ20031000. PMC 1223844. PMID 14505490.
- Smith CJ, Grigorieff N, Pearse BM (September 1998). „Clathrin coats at 21 A resolution: a cellular assembly designed to recycle multiple membrane receptors”. The EMBO Journal 17 (17): 4943–53. DOI:10.1093/emboj/17.17.4943. PMC 1170823. PMID 9724631. (Model of Clathrin assembly)
- Pérez-Gómez J, Moore I (March 2007). „Plant endocytosis: it is clathrin after all”. Current Biology : CB 17 (6): R217–9. DOI:10.1016/j.cub.2007.01.045. PMID 17371763. (Review on involvement of clathrin in plant endocytosis - proven recently)
- Royle SJ, Bright NA, Lagnado L (April 2005). „Clathrin is required for the function of the mitotic spindle”. Nature 434 (7037): 1152–7. DOI:10.1038/nature03502. PMID 15858577.
- Knuehl C, Chen CY, Manalo V, Hwang PK, Ota N, Brodsky FM (December 2006). „Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly”. Traffic (Copenhagen, Denmark) 7 (12): 1688–700. DOI:10.1111/j.1600-0854.2006.00499.x. PMID 17052248.
- Edeling MA, Smith C, Owen D (January 2006). „Life of a clathrin coat: insights from clathrin and AP structures”. Nature Reviews Molecular Cell Biology 7 (1): 32–44. DOI:10.1038/nrm1786. PMID 16493411.
Povezano
- AP180
- Ćelijska migracija
- Epsin
- Adaptin
Spoljašnje veze
- Eukaryotic Linear Motif resource motif class LIG_Clathr_ClatBox_1.html LIG_Clathr_ClatBox_1
- Eukaryotic Linear Motif resource motif class LIG_Clathr_ClatBox_2.html LIG_Clathr_ClatBox_2
- Struktura klatrina
- Membranska sinamika