Kanakinumab

Kanakinumab
Klinički podaci
Drugs.com	Monografija
Način primene	Subkutano
Farmakokinetički podaci
Poluvreme eliminacije	26 dana

Identifikatori
CAS broj	914613-48-2^Y
ATC kod	L04AC08 (WHO)
DrugBank	DB06168^Y
ChEMBL	CHEMBL1201834^Y
Hemijski podaci
Formula	C₆₄₅₂H₉₉₅₈N₁₇₂₂O₂₀₁₀S₄₂
Molarna masa	145.2 kDa

Kanakinumab (INN, Ilaris, ACZ885)^[1] je ljudsko monoklonalno antitelo koje prepoznaje at interleukin-1 beta, i ne vezuje se za druge članove interleukin-1 familije.^[2]^[3]^[4]^[5]^[6]^[7]

Reference

^ Dhimolea, Eugen (2010). „Canakinumab”. MAbs. 2 (1): 3—13. PMC 2828573 . PMID 20065636. doi:10.4161/mabs.2.1.10328.
^ Lachmann, HJ; Kone-Paut I; et al. (4. 6. 2009). „Use of canakinumab in the cryopyrin-associated periodic syndrome”. New Engl J Med. 360 (23): 2416—25. PMID 19494217. doi:10.1056/NEJMoa0810787.
^ Church LD, McDermott MF: Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders. Curr Opin Mol Ther. 2009 Feb;11(1):81-9. PMID 19169963
^ IMGT Link:http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=8836 Архивирано на сајту Wayback Machine (7. децембар 2008)
^ Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB, Leslie KS, Hachulla E, Quartier P, Gitton X, Widmer A, Patel N, Hawkins PN: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 2009 Jun 4;360(23):2416-25. PMID 19494217
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.