Keramidaza

Keramidaza
Identifikatori
EC broj3.5.1.23
CAS broj37289-06-8
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Pretraga
PMCčlanci
PubMedčlanci
NCBIproteini

Keramidaza (EC 3.5.1.23, acilsfingozinska deacilaza, glikosfingolipidna keramidna deacilaza) je enzim sa sistematskim imenom N-acilsfingozin amidohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

keramid + H2O {\displaystyle \rightleftharpoons } karboksilat + sfingozin

Reference

  1. ^ Nilsson, A. (1969). „The presence of spingomyelin- and ceramide-cleaving enzymes in the small intestinal tract”. Biochim. Biophys. Acta. 176: 339—347. PMID 5775951. 
  2. ^ Yavin, E. & Gatt, S. (1969). „Enzymatic hydrolysis of sphingolipids. 8. Further purification and properties of rat brain ceramidase”. Biochemistry. 8: 1692—1698. PMID 5805303. 

Literatura

  • Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
  • William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

  • Ceramidase на US National Library of Medicine Medical Subject Headings (MeSH)
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Hidrolaze: ugljenično-azotne nepeptidne (EC 3.5)
3.5.1: Linearni amidi /
Amidohidrolaze3.5.2: Cyclic amides/
Amidohidrolaze3.5.3: Linear amidines/
Ureohidrolaze3.5.4: Cyclic amidines/
Aminohidrolaze3.5.5: Nitrili/
Aminohidrolaze3.5.99: Drugi
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Teme
Tipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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