周期蛋白依赖性激酶6 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/c/c4/Protein_CDK6_PDB_1bi7.png/250px-Protein_CDK6_PDB_1bi7.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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1BI7、1BI8、1BLX、1G3N、1JOW、1XO2、2EUF、2F2C、3NUP、3NUX、4AUA、4EZ5、4TTH |
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識別號 |
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别名 | CDK6;, MCPH12, PLSTIRE, cyclin-dependent kinase 6, cyclin dependent kinase 6 |
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外部ID | OMIM:603368 MGI:1277162 HomoloGene:963 GeneCards:CDK6 |
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相關疾病 |
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類風濕性關節炎、microcephaly 12, primary, autosomal recessive[1] |
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為以下藥物的標靶 |
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帕布昔利布、trilaciclib、帕布昔利布、截癌寧、at-7519、AZD5438、瑞博西利[2] |
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基因位置(小鼠) |
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![小鼠5号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png) | 染色体 | 小鼠5号染色体[4] |
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| 基因座 | 5 A1|5 2.04 cM | 起始 | 3,391,485 bp[4] |
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终止 | 3,581,008 bp[4] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/77/PBB_GE_CDK6_207143_at_fs.png/250px-PBB_GE_CDK6_207143_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • 轉移酶活性 • 蛋白激酶活性 • 核苷酸結合 • 細胞週期蛋白依賴性蛋白絲氨酸/蘇氨酸激酶活性 • 激酶活性 • 蛋白质丝氨酸/苏氨酸激酶活性 • 血浆蛋白结合 • ATP結合 • 細胞週期蛋白結合 • FBXO family protein binding
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細胞組分 | • 細胞質 • 中心体 • cell projection • 細胞週期蛋白依賴性蛋白激酶全酶複合物 • ruffle • 微管组织中心 • 细胞骨架 • 细胞核 • 细胞质基质 • 核质 • cyclin D2-CDK6 complex
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生物學過程 | • 细胞分化 • lateral ventricle development • 磷酸化 • positive regulation of cell-matrix adhesion • positive regulation of fibroblast proliferation • dentate gyrus development • regulation of erythrocyte differentiation • astrocyte development • negative regulation of cell differentiation • response to virus • negative regulation of cell cycle • negative regulation of osteoblast differentiation • generation of neurons • 細胞分裂 • regulation of cell motility • protein phosphorylation • negative regulation of epithelial cell proliferation • 基因調節 • 細胞週期 • type B pancreatic cell development • negative regulation of myeloid cell differentiation • negative regulation of cellular senescence • gliogenesis • negative regulation of cell population proliferation • negative regulation of monocyte differentiation • 訊息傳遞 • regulation of G2/M transition of mitotic cell cycle • regulation of cell population proliferation • cell dedifferentiation • G1/S transition of mitotic cell cycle • negative regulation of transcription by RNA polymerase II • hematopoietic progenitor cell differentiation • Notch信号通路 • positive regulation of gene expression • 造血作用 • T cell differentiation in thymus • hematopoietic stem cell differentiation • regulation of hematopoietic stem cell differentiation • negative regulation of G1/S transition of mitotic cell cycle
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 7: 92.6 – 92.84 Mb | Chr 5: 3.39 – 3.58 Mb |
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PubMed查找 | [5] | [6] |
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維基數據 |
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