HMOX1

Heme oxygenase (decycling) 1
血红素加氧酶1（脱环）
PDB rendering based on 1n3u.
有效结构
PDB 直系同源检索：PDBe, RCSB
PDB查询代码列表

1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM

标识
代号 HMOX1; HMOX1D; HO-1; HSP32; bK286B10
扩展标识 遗传学：141250 鼠基因：96163 同源基因：31075 ChEMBL: 2823 GeneCards: HMOX1 Gene
EC編號 1.14.99.3
基因本体论描述
分子功能 · heme oxygenase (decyclizing) activity

· phospholipase D activity
· signal transducer activity
· enzyme binding
· heme binding
· protein homodimerization activity

· metal ion binding
细胞成分 · extracellular space

· nucleus
· nucleolus
· endoplasmic reticulum
· endoplasmic reticulum membrane
· cytosol
· caveola

· membrane
生物过程 · angiogenesis

· endothelial cell proliferation
· wound healing involved in inflammatory response
· negative regulation of leukocyte migration
· porphyrin-containing compound metabolic process
· heme oxidation
· cellular iron ion homeostasis
· response to oxidative stress
· intracellular protein kinase cascade
· small GTPase mediated signal transduction
· excretion
· regulation of blood pressure
· cell death
· intrinsic apoptotic signaling pathway in response to DNA damage
· smooth muscle hyperplasia
· cellular response to nutrient
· negative regulation of mast cell cytokine production
· erythrocyte homeostasis
· low-density lipoprotein particle clearance
· response to nicotine
· heme catabolic process
· response to hydrogen peroxide
· negative regulation of apoptotic process
· positive regulation of I-kappaB kinase/NF-kappaB cascade
· negative regulation of mast cell degranulation
· negative regulation of DNA binding
· negative regulation of sequence-specific DNA binding transcription factor activity
· negative regulation of neuron apoptotic process
· regulation of transcription from RNA polymerase II promoter in response to oxidative stress
· response to estrogen stimulus
· small molecule metabolic process
· positive regulation of chemokine biosynthetic process
· regulation of angiogenesis
· positive regulation of angiogenesis
· positive regulation of vasodilation
· positive regulation of smooth muscle cell proliferation
· negative regulation of smooth muscle cell proliferation
· regulation of sequence-specific DNA binding transcription factor activity
· protein homooligomerization
· iron ion homeostasis
· transmembrane transport
· cellular response to cadmium ion

· cellular response to hypoxia
Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 3162 15368
Ensembl ENSG00000100292 ENSMUSG00000005413
UniProt P09601 P14901
mRNA序列 NM_002133 NM_010442
蛋白序列 NP_002124 NP_034572
基因位置 Chr 22:
35.78 – 35.79 Mb		 Chr 8:
75.09 – 75.1 Mb
PubMed查询 [1] [2]
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血红素加氧酶1（英語：heme oxygenase 1，缩写HMOX1或HO-1）是一种血红素加氧酶（EC 1.14.99.3），是血红素代谢过程中的重要酶，它将血红素转化为胆绿素。

另见

  • HMOX2

参考文献

延伸阅读

  • Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999, 103 (1): 129–35. PMC 407858 可免费查阅. PMID 9884342. doi:10.1172/JCI4165. 
  • Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage.. Brain. 2007, 130 (6): 1643–52. PMC 2291147 可免费查阅. PMID 17525142. doi:10.1093/brain/awm095. 
  • Soares MP, Brouard S, Smith RN, Bach FH. Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunol. Rev. 2002, 184: 275–85. PMID 12086318. doi:10.1034/j.1600-065x.2001.1840124.x. 
  • Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am. J. Respir. Cell Mol. Biol. 2002, 27 (1): 8–16. PMID 12091240. doi:10.1165/ajrcmb.27.1.4862. 
  • Buelow R, Tullius SG, Volk HD. Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. Am. J. Transplant. 2002, 1 (4): 313–5. PMID 12099373. doi:10.1034/j.1600-6143.2001.10404.x. 
  • Ishikawa K. Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Curr. Pharm. Des. 2003, 9 (30): 2489–97. PMID 14529548. doi:10.2174/1381612033453767. 
  • Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic. Biol. Med. 2005, 37 (8): 1097–104. PMID 15451051. doi:10.1016/j.freeradbiomed.2004.07.008. 
  • Ozono R. New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. Current pharmaceutical biotechnology. 2006, 7 (2): 87–93. PMID 16724942. doi:10.2174/138920106776597630. 
  • Tracz MJ, Alam J, Nath KA. Physiology and pathophysiology of heme: implications for kidney disease. J. Am. Soc. Nephrol. 2007, 18 (2): 414–20. PMID 17229906. doi:10.1681/ASN.2006080894. 
  • Hill-Kapturczak N, Agarwal A. Haem oxygenase-1--a culprit in vascular and renal damage?. Nephrol. Dial. Transplant. 2007, 22 (6): 1495–9. PMID 17389623. doi:10.1093/ndt/gfm093. 
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双加氧酶（英语：Oxidoreductase）类，包括类固醇羟化酶（英语：steroid hydroxylases）（EC 1.14）
1.14.11（英语：List of EC numbers (EC 1)#EC 1.14.11 With 2-oxoglutarate as one donor.2C and incorporation of one atom each of oxygen into both donors）：以α-酮戊二酸为供体
1.14.11：以NADH或NADPH为供体
  • 苯1,2-双加氧酶
  • 5-吡哆酸双加氧酶
  • 邻苯二甲酸1,2-双加氧酶
  • 苯甲酸1,2-双加氧酶
  • 甲苯双加氧酶
  • 萘1,2-双加氧酶
  • 对苯二酸1,2-双加氧酶
  • 一氧化氮双加氧酶
  • 脱镁叶绿酸a加氧酶
  • 苯甲酰辅酶A双加氧酶
  • 咔唑1,9a-双加氧酶
1.14.13（英语：List of EC numbers (EC 1)#EC 1.14.13 With NADH or NADPH as one donor.2C and incorporation of one atom of oxygen）：以NADH或NADPH为供体
  • 含黄素单加氧酶（英语：Flavin-containing monooxygenase）（FMO1（英语：FMO1）、FMO2（英语：FMO2）、FMO3（英语：FMO3）、FMO4（英语：FMO4）、FMO5（英语：FMP5））
  • 一氧化氮合酶（NOS1（英语：NOS1）、NOS2（英语：NOS2）、NOS3（英语：NOS3））
  • 胆固醇7α-羟化酶
  • 甲烷单加氧酶
  • CYP3A4
  • 羊毛固醇14α-脱甲基酶
1.14.14：以还原型黄素黄素或黄素蛋白为供体
1.14.15：以还原型铁硫蛋白为供体
1.14.16：以还原型蝶啶为受体
1.14.17：以还原型抗坏血酸为受体
1.14.18
1.14.19
  • 硬脂酰辅酶A脱饱和酶1
1.14.20：以α-酮戊二酸为受体
1.14.99：杂项
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3（英语：Template:Ligases CO CS and CN）/4/5-6