RARB |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Protein_RARB_PDB_1dsz.png/250px-Protein_RARB_PDB_1dsz.png) |
Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1HRA, 1XAP, 4DM6, 4DM8, 4JYG, 4JYH, 4JYI | | |
Ідентифікатори |
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Символи | RARB, HAP, MCOPS12, NR1B2, RRB2, RARbeta1, retinoic acid receptor beta, RARbeta |
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Зовнішні ІД | OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB |
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Пов'язані генетичні захворювання |
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morbid obesity, syndromic microphthalmia[1] |
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Реагує на сполуку |
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adapalene, alitretinoin, tamibarotene, tazarotene, третиноїн[2] |
Онтологія гена |
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Молекулярна функція | • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • зв'язування з іоном металу • steroid hormone receptor activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding • retinoid X receptor binding • GO:0000975 transcription cis-regulatory region binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity |
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Клітинна компонента | • цитоплазма • нуклеоплазма • клітинне ядро • RNA polymerase II transcription regulator complex |
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Біологічний процес | • growth plate cartilage development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • Нейрогенез • ureteric bud development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cartilage development • multicellular organism growth • embryonic eye morphogenesis • positive regulation of programmed cell death • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • retinal pigment epithelium development • transcription, DNA-templated • outflow tract septum morphogenesis • negative regulation of chondrocyte differentiation • retinoic acid receptor signaling pathway • regulation of myelination • retina development in camera-type eye • positive regulation of neuron differentiation • positive regulation of cell population proliferation • positive regulation of apoptotic process • ventricular cardiac muscle cell differentiation • transcription initiation from RNA polymerase II promoter • bone development • embryonic digestive tract development • striatum development • GO:0072468 сигнальна трансдукція • negative regulation of cell population proliferation • glandular epithelial cell development • steroid hormone mediated signaling pathway • embryonic hindlimb morphogenesis • liver development • multicellular organism development • hormone-mediated signaling pathway • диференціація клітин • response to retinoic acid • response to lipid • gland development • bone morphogenesis • epithelium development • cellular response to retinoic acid |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/2/21/PBB_GE_RARB_205080_at_fs.png/250px-PBB_GE_RARB_205080_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/3/36/PBB_GE_RARB_208412_s_at_fs.png/250px-PBB_GE_RARB_208412_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/5/56/PBB_GE_RARB_208530_s_at_fs.png/250px-PBB_GE_RARB_208530_s_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_000965 NM_001290216 NM_001290217 NM_001290266 NM_001290276
| NM_001290277 NM_001290300 NM_016152 |
| | NM_001289760 NM_001289761 NM_001289762 NM_011243 |
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RefSeq (білок) | NP_000956 NP_001277145 NP_001277146 NP_001277195 NP_001277205
| NP_001277206 NP_001277229 NP_057236 NP_001277146.1 NP_001277205.1 NP_057236.1 |
| | NP_001276689 NP_001276690 NP_001276691 NP_035373 |
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Локус (UCSC) | Хр. 3: 24.69 – 25.6 Mb | Хр. 14: 5.65 – 6.04 Mb |
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PubMed search | [3] | [4] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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