25-羥基維生素D3 1-α-羥化酶 |
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識別號 |
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别名 | CYP27B1;, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, cytochrome P450 family 27 subfamily B member 1 |
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外部ID | OMIM:609506 MGI:1098274 HomoloGene:37139 GeneCards:CYP27B1 |
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EC number | 1.14.15.18 |
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相關疾病 |
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1-alpha-hydroxylase deficiency[1] |
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基因位置(小鼠) |
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![小鼠10号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | 染色体 | 小鼠10号染色体[3] |
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| 基因座 | 10|10 D3 | 起始 | 126,884,119 bp[3] |
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终止 | 126,888,875 bp[3] |
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基因本體 |
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分子功能 | • iron ion binding • 金屬離子結合 • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • calcidiol 1-monooxygenase activity
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細胞組分 | • 細胞質 • 膜 • mitochondrial membranes • mitochondrial outer membrane • 線粒體
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生物學過程 | • bone mineralization • response to vitamin D • calcium ion homeostasis • response to interferon-gamma • vitamin D metabolic process • regulation of bone mineralization • positive regulation of keratinocyte differentiation • G1 to G0 transition • response to estrogen • response to lipopolysaccharide • negative regulation of calcidiol 1-monooxygenase activity • 蛻膜化 • vitamin metabolic process • negative regulation of cell growth • calcitriol biosynthetic process from calciol • positive regulation of vitamin D 24-hydroxylase activity • vitamin D catabolic process • positive regulation of vitamin D receptor signaling pathway • calcium ion transport • negative regulation of cell population proliferation
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 12: 57.76 – 57.77 Mb | Chr 10: 126.88 – 126.89 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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